1a7h: Difference between revisions

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[[Image:1a7h.~~gif~~|left|200px]]

[[Image:1a7h.png|left|200px]]

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~~'''~~GAMMA S CRYSTALLIN C-TERMINAL DOMAIN~~'''~~

===GAMMA S CRYSTALLIN C-TERMINAL DOMAIN===

~~==Overview==~~

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The ~~2-domain gammaS-crystallin~~, ~~a highly conserved early evolutionary off-shoot of the gamma-crystallin family~~, ~~is located in~~ the ~~water-rich region of eye lenses. The expressed C-terminal domain, gammaS-C, has been crystallized and~~ the 2.~~56 A X-ray structure determined~~. ~~There are two domains in the asymmetric unit which pair about a distorted twofold axis. One of the domains has an altered conformation in a highly conserved region of the protein~~, the ~~tyrosine corner~~. ~~The distorted gammaS~~-~~C dimer of domains is compared with the highly symmetrical, equivalent recombinant dimer of C~~-terminal domains from gammaB-crystallin. Sequence changes close to the interface, that distinguish gammaS from the other gamma-crystallins, are examined in order to evaluate their role in symmetrical domain pairing.

The line below this paragraph, {{ABSTRACT_PUBMED_9681865}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 9681865 is the PubMed ID number.

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==About this Structure==

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[[Category: Gamma crystallin s]]

[[Category: Multigene family]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 09~~:55:47 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:18:33 2008''

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-[[Image:1a7h.gif|left|200px]]
+{{Seed}}
+[[Image:1a7h.png|left|200px]]
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 {{STRUCTURE_1a7h|  PDB=1a7h  |  SCENE=  }}
-'''GAMMA S CRYSTALLIN C-TERMINAL DOMAIN'''
+===GAMMA S CRYSTALLIN C-TERMINAL DOMAIN===
-==Overview==
+<!--
-The 2-domain gammaS-crystallin, a highly conserved early evolutionary off-shoot of the gamma-crystallin family, is located in the water-rich region of eye lenses. The expressed C-terminal domain, gammaS-C, has been crystallized and the 2.56 A X-ray structure determined. There are two domains in the asymmetric unit which pair about a distorted twofold axis. One of the domains has an altered conformation in a highly conserved region of the protein, the tyrosine corner. The distorted gammaS-C dimer of domains is compared with the highly symmetrical, equivalent recombinant dimer of C-terminal domains from gammaB-crystallin. Sequence changes close to the interface, that distinguish gammaS from the other gamma-crystallins, are examined in order to evaluate their role in symmetrical domain pairing.
+The line below this paragraph, {{ABSTRACT_PUBMED_9681865}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9681865 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9681865}}
 ==About this Structure==
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 [[Category: Gamma crystallin s]]
 [[Category: Multigene family]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 09:55:47 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:18:33 2008''