1a8a: Difference between revisions

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[[Image:1a8a.gif|left|200px]]
{{Seed}}
[[Image:1a8a.png|left|200px]]


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{{STRUCTURE_1a8a|  PDB=1a8a  |  SCENE=  }}  
{{STRUCTURE_1a8a|  PDB=1a8a  |  SCENE=  }}  


'''RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOSERINE'''
===RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOSERINE===




==Overview==
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Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for Ca(2+)-binding interfacial membrane proteins such as annexins, protein kinase C, and certain coagulation proteins. Crystal structures of Ca(2+)-annexin V complexes with phospholipid polar heads provide molecular details of 'Ca(2+)-bridges' as key features in the membrane attachment exhibited by these proteins. Distinct binding sites for phospholipid head groups are observed, including a novel, double-Ca2+ recognition site for phosphoserine that may serve as a phosphatidylserine receptor site in vivo.
The line below this paragraph, {{ABSTRACT_PUBMED_7583670}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 7583670 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7583670}}


==About this Structure==
==About this Structure==
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[[Category: Membrane binding protein]]
[[Category: Membrane binding protein]]
[[Category: Phospholipid analog]]
[[Category: Phospholipid analog]]
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