1a9l: Difference between revisions

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[[Image:1a9l.jpg|left|200px]]
{{Seed}}
[[Image:1a9l.png|left|200px]]


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{{STRUCTURE_1a9l|  PDB=1a9l  |  SCENE=  }}  
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'''SOLUTION STRUCTURE OF A SUBSTRATE FOR THE ARCHAEAL PRE-TRNA SPLICING ENDONUCLEASES: THE BULGE-HELIX-BULGE MOTIF, NMR, 12 STRUCTURES'''
===SOLUTION STRUCTURE OF A SUBSTRATE FOR THE ARCHAEAL PRE-TRNA SPLICING ENDONUCLEASES: THE BULGE-HELIX-BULGE MOTIF, NMR, 12 STRUCTURES===




==Overview==
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The structure of the bulge-helix-bulge motif that constitutes the intron/exon splice site in H. volcanii pre-tRNATrp has been determined by NMR spectroscopy. The conformations of the two 3 nt bulges, where the pre-tRNA is cleaved, are stabilized by stacking interactions between bulge nucleotides and bases in the adjacent Watson-Crick helices and by a network of backbone hydrogen bonds. Both bulges are presented on the same minor groove face of the central 4 bp helix, and the overall structure has approximate two-fold symmetry, which makes it well-suited for attack by archaeal splicing endonucleases, which are symmetric dimers.
The line below this paragraph, {{ABSTRACT_PUBMED_9660971}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9660971 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9660971}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A9L OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A9L OCA].  


==Reference==
==Reference==
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[[Category: Ribonucleic acid]]
[[Category: Ribonucleic acid]]
[[Category: Rna structure]]
[[Category: Rna structure]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:00:58 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:26:13 2008''

Revision as of 13:26, 30 June 2008

File:1a9l.png

Template:STRUCTURE 1a9l

SOLUTION STRUCTURE OF A SUBSTRATE FOR THE ARCHAEAL PRE-TRNA SPLICING ENDONUCLEASES: THE BULGE-HELIX-BULGE MOTIF, NMR, 12 STRUCTURES

Template:ABSTRACT PUBMED 9660971

About this Structure

Full experimental information is available from OCA.

Reference

Solution structure of a substrate for the archaeal pre-tRNA splicing endonucleases: the bulge-helix-bulge motif., Diener JL, Moore PB, Mol Cell. 1998 May;1(6):883-94. PMID:9660971

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