1a9m: Difference between revisions

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[[Image:1a9m.gif|left|200px]]
{{Seed}}
[[Image:1a9m.png|left|200px]]


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{{STRUCTURE_1a9m|  PDB=1a9m  |  SCENE=  }}  
{{STRUCTURE_1a9m|  PDB=1a9m  |  SCENE=  }}  


'''G48H MUTANT OF HIV-1 PROTEASE IN COMPLEX WITH A PEPTIDIC INHIBITOR U-89360E'''
===G48H MUTANT OF HIV-1 PROTEASE IN COMPLEX WITH A PEPTIDIC INHIBITOR U-89360E===




==Overview==
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The crystal structure of human immunodeficiency virus type 1 (HIV-1) protease mutant G48H with peptidic inhibitor U-89360E is described. Comparison with wild-type protease-inhibitor complex shows that mutation of flap residue 48 to histidine allows stabilizing van der Waals contacts between the side chains of His48 and Phe53 as well as between His48 and the P2' and P3' inhibitor subsites. The flap region is less mobile than in the wild-type enzyme. A model of saquinavir-resistant mutant protease G48V in complex with saquinavir predicts interactions similar to those found in the G48H crystal. Energetic calculations confirm the similarity of the His48 and Val48 interactions.
The line below this paragraph, {{ABSTRACT_PUBMED_9450540}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9450540 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9450540}}


==About this Structure==
==About this Structure==
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[[Category: Drug resistant]]
[[Category: Drug resistant]]
[[Category: Mutation]]
[[Category: Mutation]]
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