1ad6: Difference between revisions

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[[Image:1ad6.gif|left|200px]]
{{Seed}}
[[Image:1ad6.png|left|200px]]


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{{STRUCTURE_1ad6|  PDB=1ad6  |  SCENE=  }}  
{{STRUCTURE_1ad6|  PDB=1ad6  |  SCENE=  }}  


'''DOMAIN A OF HUMAN RETINOBLASTOMA TUMOR SUPPRESSOR'''
===DOMAIN A OF HUMAN RETINOBLASTOMA TUMOR SUPPRESSOR===




==Overview==
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The pocket region of retinoblastoma tumour suppressor (Rb) is essential for tumour suppressing activity. The Rb pocket is primarily composed of two domains, A and B. We have determined the X-ray crystal structure of domain A (residues 378-562) at 2.3 A resolution. Domain A consists of nine alpha-helices. The overall arrangement of helices in domain A is remarkably similar to the cyclin-box folds found in the crystal structures of cyclin A and TFIIB. This structure, along with domain B which is predicted to be homologous to the cyclin-box, suggests that the Rb pocket is composed of two cyclin-box fold domains. We present the structural/functional features of the Rb pocket, and the potential binding region for cellular or viral proteins within domain A.
The line below this paragraph, {{ABSTRACT_PUBMED_9145110}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_9145110}}


==About this Structure==
==About this Structure==
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[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
[[Category: Tumor suppressor]]
[[Category: Tumor suppressor]]
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