1ah7: Difference between revisions

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[[Image:1ah7.gif|left|200px]]
{{Seed}}
[[Image:1ah7.png|left|200px]]


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{{STRUCTURE_1ah7|  PDB=1ah7  |  SCENE=  }}  
{{STRUCTURE_1ah7|  PDB=1ah7  |  SCENE=  }}  


'''PHOSPHOLIPASE C FROM BACILLUS CEREUS'''
===PHOSPHOLIPASE C FROM BACILLUS CEREUS===




==Overview==
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Both the phosphatidylinositol-hydrolysing and the phosphatidylcholine-hydrolysing phospholipases C have been implicated in the generation of second messengers in mammalian cells. The phosphatidylcholine-hydrolysing phospholipase C (PLC) from Bacillus cereus, a monomeric protein containing 245 amino-acid residues, is similar to some of the corresponding mammalian proteins. This, together with the fact that the bacterial enzyme can mimic the action of mammalian PLC in causing, for example, enhanced prostaglandin biosynthesis, suggests that B. cereus PLC can be used as a model for the hitherto poorly characterized mammalian PLCs. We report here the three-dimensional structure of B. cereus PLC at 1.5 A resolution. The enzyme is an all-helix protein belonging to a novel structural class and contains, at least in the crystalline state, three Zn2+ in the active site. We also present preliminary results from a study at 1.9 A resolution of the complex between PLC and inorganic phosphate (Pi) which indicate that the substrate binds directly to the metal ions.
The line below this paragraph, {{ABSTRACT_PUBMED_2493587}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 2493587 is the PubMed ID number.
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{{ABSTRACT_PUBMED_2493587}}


==About this Structure==
==About this Structure==
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[[Category: Lipase]]
[[Category: Lipase]]
[[Category: Phospholipid hydrolysis]]
[[Category: Phospholipid hydrolysis]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:15:55 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:50:43 2008''

Revision as of 13:50, 30 June 2008

File:1ah7.png

Template:STRUCTURE 1ah7

PHOSPHOLIPASE C FROM BACILLUS CEREUS

Template:ABSTRACT PUBMED 2493587

About this Structure

1AH7 is a Single protein structure of sequence from Bacillus cereus. Full crystallographic information is available from OCA.

Reference

High-resolution (1.5 A) crystal structure of phospholipase C from Bacillus cereus., Hough E, Hansen LK, Birknes B, Jynge K, Hansen S, Hordvik A, Little C, Dodson E, Derewenda Z, Nature. 1989 Mar 23;338(6213):357-60. PMID:2493587

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