1ahm: Difference between revisions

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[[Image:1ahm.gif|left|200px]]
{{Seed}}
[[Image:1ahm.png|left|200px]]


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{{STRUCTURE_1ahm|  PDB=1ahm  |  SCENE=  }}  
{{STRUCTURE_1ahm|  PDB=1ahm  |  SCENE=  }}  


'''DER F 2, THE MAJOR MITE ALLERGEN FROM DERMATOPHAGOIDES FARINAE, NMR, 10 STRUCTURES'''
===DER F 2, THE MAJOR MITE ALLERGEN FROM DERMATOPHAGOIDES FARINAE, NMR, 10 STRUCTURES===




==Overview==
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House dust mites cause heavy atopic diseases such as asthma and dermatitis. Among allergens from Dermatophagoides farinae, Der f 2 shows the highest positive rate for atopic patients, but its biological function in mites has been perfectly unknown, as well as the functions of its homologs in human and other animals. We have determined the tertiary structure of Der f 2 by multidimensional nuclear magnetic resonance spectroscopy. Der f 2 was found to be a single-domain protein of immunoglobulin fold, and its structure was the most similar to those of the two regulatory domains of transglutaminase. This fact, binding to the bacterial surface, and other small pieces of information hinted that Der f 2 is related to the innate antibacterial defense system in mites. The immunoglobulin E epitopes are also discussed on the basis of the tertiary structure.
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{{ABSTRACT_PUBMED_9417088}}


==About this Structure==
==About this Structure==
1AHM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dermatophagoides_farinae Dermatophagoides farinae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AHM OCA].  
1AHM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dermatophagoides_farinae Dermatophagoides farinae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AHM OCA].  


==Reference==
==Reference==
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[[Category: Allergen]]
[[Category: Allergen]]
[[Category: Immunoglobulin fold]]
[[Category: Immunoglobulin fold]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:16:51 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:52:01 2008''

Revision as of 13:52, 30 June 2008

File:1ahm.png

Template:STRUCTURE 1ahm

DER F 2, THE MAJOR MITE ALLERGEN FROM DERMATOPHAGOIDES FARINAE, NMR, 10 STRUCTURES

Template:ABSTRACT PUBMED 9417088

About this Structure

1AHM is a Single protein structure of sequence from Dermatophagoides farinae. Full experimental information is available from OCA.

Reference

Solution structure of Der f 2, the major mite allergen for atopic diseases., Ichikawa S, Hatanaka H, Yuuki T, Iwamoto N, Kojima S, Nishiyama C, Ogura K, Okumura Y, Inagaki F, J Biol Chem. 1998 Jan 2;273(1):356-60. PMID:9417088

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