1alv: Difference between revisions

Line 1:

[[Image:1alv.~~gif~~|left|200px]]

[[Image:1alv.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~CALCIUM BOUND DOMAIN VI OF PORCINE CALPAIN~~'''~~

===CALCIUM BOUND DOMAIN VI OF PORCINE CALPAIN===

~~==Overview==~~

<!--

The ~~three dimensional structure of calcium-bound domain VI of porcine calpain has been determined to 1.9 A resolution. The crystal structure reveals five EF-hands~~, ~~one more than previously suggested. There are two EF-hand pairs~~, ~~one pair (EF1-EF2) displays an 'open' conformation and~~ the ~~other~~ (~~EF3-EF4~~) ~~a 'closed' conformation. Unusually~~, ~~a calcium atom~~ is ~~found at the C-terminal end of~~ the ~~calcium binding loop of EF4~~. ~~With two additional residues in the calcium binding loop, the fifth EF-hand (EF5) is in a 'closed' conformation. EF5 pairs up with the corresponding fifth EF~~-~~hand of a non~~-crystallographically related molecule. Considering the EF5's role in a homodimer formation of domain VI, we suggest a model for the assembly of heterodimeric calpain. The crystal structure of a Ca2+ bound domain VI-inhibitor (PD150606) complex has been refined to 2.1 A resolution. A possible mode for calpain inhibition is discussed.

The line below this paragraph, {{ABSTRACT_PUBMED_9228946}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 9228946 is the PubMed ID number.

-->

==About this Structure==

Line 30:

Line 34:

[[Category: Calmodulin like]]

[[Category: Domain of cystein protease]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 10~~:25:49 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:07:04 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1alv.gif|left|200px]]
+{{Seed}}
+[[Image:1alv.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1alv|  PDB=1alv  |  SCENE=  }}
-'''CALCIUM BOUND DOMAIN VI OF PORCINE CALPAIN'''
+===CALCIUM BOUND DOMAIN VI OF PORCINE CALPAIN===
-==Overview==
+<!--
-The three dimensional structure of calcium-bound domain VI of porcine calpain has been determined to 1.9 A resolution. The crystal structure reveals five EF-hands, one more than previously suggested. There are two EF-hand pairs, one pair (EF1-EF2) displays an 'open' conformation and the other (EF3-EF4) a 'closed' conformation. Unusually, a calcium atom is found at the C-terminal end of the calcium binding loop of EF4. With two additional residues in the calcium binding loop, the fifth EF-hand (EF5) is in a 'closed' conformation. EF5 pairs up with the corresponding fifth EF-hand of a non-crystallographically related molecule. Considering the EF5's role in a homodimer formation of domain VI, we suggest a model for the assembly of heterodimeric calpain. The crystal structure of a Ca2+ bound domain VI-inhibitor (PD150606) complex has been refined to 2.1 A resolution. A possible mode for calpain inhibition is discussed.
+The line below this paragraph, {{ABSTRACT_PUBMED_9228946}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9228946 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9228946}}
 ==About this Structure==
@@ Line 30: / Line 34: @@
 [[Category: Calmodulin like]]
 [[Category: Domain of cystein protease]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:25:49 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:07:04 2008''