1ang: Difference between revisions

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[[Image:1ang.~~jpg~~|left|200px]]

[[Image:1ang.png|left|200px]]

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~~'''~~CRYSTAL STRUCTURE OF HUMAN ANGIOGENIN REVEALS THE STRUCTURAL BASIS FOR ITS FUNCTIONAL DIVERGENCE FROM RIBONUCLEASE~~'''~~

===CRYSTAL STRUCTURE OF HUMAN ANGIOGENIN REVEALS THE STRUCTURAL BASIS FOR ITS FUNCTIONAL DIVERGENCE FROM RIBONUCLEASE===

~~==Overview==~~

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~~Angiogenin~~, ~~a potent inducer of neovascularization~~, is the ~~only angiogenic molecule known~~ to ~~exhibit ribonucleolytic activity. Its overall structure,~~ as ~~determined~~ at 2.~~4 A~~, is ~~similar to that of pancreatic ribonuclease A, but it differs markedly in several distinct areas, particularly the ribonucleolytic active center and~~ the ~~putative receptor binding site, both of which are critically involved in biological function~~. ~~Most strikingly, the site that is spatially analogous to that for pyrimidine binding in ribonuclease A differs significantly in conformation and is "obstructed" by glutamine~~-~~117. Movement of this and adjacent residues may be required for substrate binding to angiogenin and, hence, constitute a key part of its mechanism of action.~~

The line below this paragraph, {{ABSTRACT_PUBMED_8159679}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 8159679 is the PubMed ID number.

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==About this Structure==

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[[Category: Shapiro, R.]]

[[Category: Vallee, B L.]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 10~~:28:51 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:13:13 2008''

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-[[Image:1ang.jpg|left|200px]]
+{{Seed}}
+[[Image:1ang.png|left|200px]]
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 {{STRUCTURE_1ang|  PDB=1ang  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF HUMAN ANGIOGENIN REVEALS THE STRUCTURAL BASIS FOR ITS FUNCTIONAL DIVERGENCE FROM RIBONUCLEASE'''
+===CRYSTAL STRUCTURE OF HUMAN ANGIOGENIN REVEALS THE STRUCTURAL BASIS FOR ITS FUNCTIONAL DIVERGENCE FROM RIBONUCLEASE===
-==Overview==
+<!--
-Angiogenin, a potent inducer of neovascularization, is the only angiogenic molecule known to exhibit ribonucleolytic activity. Its overall structure, as determined at 2.4 A, is similar to that of pancreatic ribonuclease A, but it differs markedly in several distinct areas, particularly the ribonucleolytic active center and the putative receptor binding site, both of which are critically involved in biological function. Most strikingly, the site that is spatially analogous to that for pyrimidine binding in ribonuclease A differs significantly in conformation and is "obstructed" by glutamine-117. Movement of this and adjacent residues may be required for substrate binding to angiogenin and, hence, constitute a key part of its mechanism of action.
+The line below this paragraph, {{ABSTRACT_PUBMED_8159679}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 8159679 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_8159679}}
 ==About this Structure==
@@ Line 27: / Line 31: @@
 [[Category: Shapiro, R.]]
 [[Category: Vallee, B L.]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:28:51 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:13:13 2008''