1apm: Difference between revisions

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[[Image:1apm.gif|left|200px]]
{{Seed}}
[[Image:1apm.png|left|200px]]


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{{STRUCTURE_1apm|  PDB=1apm  |  SCENE=  }}  
{{STRUCTURE_1apm|  PDB=1apm  |  SCENE=  }}  


'''2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT'''
===2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT===




==Overview==
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. A mutant (Serl39Ala) of the mouse recombinant catalytic (C) subunit of cAMP-dependent protein kinase was co-crystallized with a peptide inhibitor, PKI(5-24), and MEGA-8 (octanoyl-N-methylglucamide) detergent. This structure was refined using all observed data (30 248 reflections) between 30 and 1.95 A resolution to an R factor of 0.186. R.m.s. deviations of bond lengths and bond angles are 0.013 A and 2.3 degrees, respectively. The final model has 3075 atoms (207 solvent) with a mean B factor of 31.9 A(2). The placement of invariant protein-kinase residues and most C:PKI(5-24) interactions were confirmed, but register errors affecting residues 55-64 and 309-339 were corrected during refinement by shifting the affected sequences toward the C terminus along the previously determined backbone path. New details of C:PKI(5-24) interactions and the Ser338 autophosphorylation site are described, and the acyl group binding site near the catalytic subunit NH(2) terminus is identified.
The line below this paragraph, {{ABSTRACT_PUBMED_15299526}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15299526 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15299526}}


==About this Structure==
==About this Structure==
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[[Category: Xuong, N H.]]
[[Category: Xuong, N H.]]
[[Category: Zheng, J.]]
[[Category: Zheng, J.]]
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