1apo: Difference between revisions

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[[Image:1apo.gif|left|200px]]
{{Seed}}
[[Image:1apo.png|left|200px]]


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{{STRUCTURE_1apo|  PDB=1apo  |  SCENE=  }}  
{{STRUCTURE_1apo|  PDB=1apo  |  SCENE=  }}  


'''THREE-DIMENSIONAL STRUCTURE OF THE APO FORM OF THE N-TERMINAL EGF-LIKE MODULE OF BLOOD COAGULATION FACTOR X AS DETERMINED BY NMR SPECTROSCOPY AND SIMULATED FOLDING'''
===THREE-DIMENSIONAL STRUCTURE OF THE APO FORM OF THE N-TERMINAL EGF-LIKE MODULE OF BLOOD COAGULATION FACTOR X AS DETERMINED BY NMR SPECTROSCOPY AND SIMULATED FOLDING===




==Overview==
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The three-dimensional structure of a 42-residue fragment containing the N-terminal EGF-like module of blood coagulation factor X was determined by means of 2D NMR spectroscopy and computer simulation. The spectroscopic data consisted of 370 NOE distances and 27 dihedral angle constraints. These were used to generate peptide conformations by molecular dynamics simulation. The simulations used a novel functional form for the constraint potentials and were performed with two time steps to ensure rapid execution. Apart from preliminary runs to aid assignment of NOEs, 60 runs resulted in 13 accepted structures, which have two antiparallel beta sheets, no alpha helices, and five tight turns. There is no hydrophobic cluster. The root mean square deviation for the backbone of the 13 conformations is 0.65 +/- 0.11 A against their mean conformation. About half of the side chains have well-defined structure. The overall conformation is similar to that of murine EGF.
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{{ABSTRACT_PUBMED_1627540}}


==About this Structure==
==About this Structure==
1APO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1APO OCA].  
1APO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1APO OCA].  


==Reference==
==Reference==
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[[Category: Ullner, M.]]
[[Category: Ullner, M.]]
[[Category: Coagulation factor]]
[[Category: Coagulation factor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:33:34 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:22:04 2008''

Revision as of 14:22, 30 June 2008

File:1apo.png

Template:STRUCTURE 1apo

THREE-DIMENSIONAL STRUCTURE OF THE APO FORM OF THE N-TERMINAL EGF-LIKE MODULE OF BLOOD COAGULATION FACTOR X AS DETERMINED BY NMR SPECTROSCOPY AND SIMULATED FOLDING

Template:ABSTRACT PUBMED 1627540

About this Structure

1APO is a Single protein structure of sequence from Bos taurus. Full experimental information is available from OCA.

Reference

Three-dimensional structure of the apo form of the N-terminal EGF-like module of blood coagulation factor X as determined by NMR spectroscopy and simulated folding., Ullner M, Selander M, Persson E, Stenflo J, Drakenberg T, Teleman O, Biochemistry. 1992 Jul 7;31(26):5974-83. PMID:1627540

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