1aum: Difference between revisions

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[[Image:1aum.gif|left|200px]]
{{Seed}}
[[Image:1aum.png|left|200px]]


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{{STRUCTURE_1aum|  PDB=1aum  |  SCENE=  }}  
{{STRUCTURE_1aum|  PDB=1aum  |  SCENE=  }}  


'''HIV CAPSID C-TERMINAL DOMAIN (CAC146)'''
===HIV CAPSID C-TERMINAL DOMAIN (CAC146)===




==Overview==
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The carboxyl-terminal domain, residues 146 to 231, of the human immunodeficiency virus-1 (HIV-1) capsid protein [CA(146-231)] is required for capsid dimerization and viral assembly. This domain contains a stretch of 20 residues, called the major homology region (MHR), which is conserved across retroviruses and is essential for viral assembly, maturation, and infectivity. The crystal structures of CA(146-231) and CA(151-231) reveal that the globular domain is composed of four helices and an extended amino-terminal strand. CA(146-231) dimerizes through parallel packing of helix 2 across a dyad. The MHR is distinct from the dimer interface and instead forms an intricate hydrogen-bonding network that interconnects strand 1 and helices 1 and 2. Alignment of the CA(146-231) dimer with the crystal structure of the capsid amino-terminal domain provides a model for the intact protein and extends models for assembly of the central conical core of HIV-1.
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{{ABSTRACT_PUBMED_9346481}}


==About this Structure==
==About this Structure==
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[[Category: Core protein]]
[[Category: Core protein]]
[[Category: Hiv]]
[[Category: Hiv]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:42:43 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:37:30 2008''

Revision as of 14:37, 30 June 2008

File:1aum.png

Template:STRUCTURE 1aum

HIV CAPSID C-TERMINAL DOMAIN (CAC146)

Template:ABSTRACT PUBMED 9346481

About this Structure

1AUM is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein., Gamble TR, Yoo S, Vajdos FF, von Schwedler UK, Worthylake DK, Wang H, McCutcheon JP, Sundquist WI, Hill CP, Science. 1997 Oct 31;278(5339):849-53. PMID:9346481

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