1avf: Difference between revisions

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[[Image:1avf.~~gif~~|left|200px]]

[[Image:1avf.png|left|200px]]

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~~'''~~ACTIVATION INTERMEDIATE 2 OF HUMAN GASTRICSIN FROM HUMAN STOMACH~~'''~~

===ACTIVATION INTERMEDIATE 2 OF HUMAN GASTRICSIN FROM HUMAN STOMACH===

~~==Overview==~~

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The ~~crystal structure of an activation intermediate of human gastricsin has been determined~~ at 2.~~4 A resolution~~. ~~The human digestive enzyme gastricsin (pepsin C~~) is ~~an aspartic proteinase that is synthesized as~~ the ~~inactive precursor (zymogen) progastricsin (pepsinogen C or hPGC)~~. ~~In the zymogen, a positively~~-~~charged N~~-terminal prosegment of 43 residues (Ala 1p-Leu 43p; the suffix 'p' refers to the prosegment) sterically prevents the approach of a substrate to the active site. Zymogen conversion occurs in an autocatalytic and stepwise fashion at low pH through the formation of intermediates. The structure of the non-covalent complex of a partially-cleaved peptide of the prosegment (Ala 1p-Phe 26p) with mature gastricsin (Ser 1-Ala 329) suggests an activation pathway that may be common to all gastric aspartic proteinases.

The line below this paragraph, {{ABSTRACT_PUBMED_9406551}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 9406551 is the PubMed ID number.

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==About this Structure==

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[[Category: Gastricsin]]

[[Category: Intermediate]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 10~~:44:28 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:40:32 2008''

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-[[Image:1avf.gif|left|200px]]
+{{Seed}}
+[[Image:1avf.png|left|200px]]
 <!--
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 {{STRUCTURE_1avf|  PDB=1avf  |  SCENE=  }}
-'''ACTIVATION INTERMEDIATE 2 OF HUMAN GASTRICSIN FROM HUMAN STOMACH'''
+===ACTIVATION INTERMEDIATE 2 OF HUMAN GASTRICSIN FROM HUMAN STOMACH===
-==Overview==
+<!--
-The crystal structure of an activation intermediate of human gastricsin has been determined at 2.4 A resolution. The human digestive enzyme gastricsin (pepsin C) is an aspartic proteinase that is synthesized as the inactive precursor (zymogen) progastricsin (pepsinogen C or hPGC). In the zymogen, a positively-charged N-terminal prosegment of 43 residues (Ala 1p-Leu 43p; the suffix 'p' refers to the prosegment) sterically prevents the approach of a substrate to the active site. Zymogen conversion occurs in an autocatalytic and stepwise fashion at low pH through the formation of intermediates. The structure of the non-covalent complex of a partially-cleaved peptide of the prosegment (Ala 1p-Phe 26p) with mature gastricsin (Ser 1-Ala 329) suggests an activation pathway that may be common to all gastric aspartic proteinases.
+The line below this paragraph, {{ABSTRACT_PUBMED_9406551}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9406551 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9406551}}
 ==About this Structure==
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 [[Category: Gastricsin]]
 [[Category: Intermediate]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:44:28 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:40:32 2008''