1b03: Difference between revisions

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[[Image:1b03.gif|left|200px]]
{{Seed}}
[[Image:1b03.png|left|200px]]


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{{STRUCTURE_1b03|  PDB=1b03  |  SCENE=  }}  
{{STRUCTURE_1b03|  PDB=1b03  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF THE ANTIBODY-BOUND HIV-1IIIB V3 PEPTIDE'''
===SOLUTION STRUCTURE OF THE ANTIBODY-BOUND HIV-1IIIB V3 PEPTIDE===




==Overview==
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The refined solution structure of an 18-residue HIV-1IIIB V3 peptide in complex with the Fv fragment of an anti-gp120 antibody reveals an unexpected type VI beta-turn comprising residues RGPG at the center of a beta-hairpin. The central glycine and proline of this turn are linked by a cis peptide bond. The residues of the turn interact extensively with the antibody Fv. 15N[1H] NOE measurements show that the backbone of the peptide, including the central QRGPGR loop, is well ordered in the complex. The solution structure is significantly different from the X-ray structures of HIV-1MN V3 peptides bound to anti-peptide antibodies. These differences could be due to a two-residue (QR) insertion preceding the GPGR sequence in the HIV-1IIIB strain, and the much longer peptide epitope immobilized by the anti-gp120 antibody.
The line below this paragraph, {{ABSTRACT_PUBMED_10201400}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10201400 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10201400}}


==About this Structure==
==About this Structure==
1B03 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B03 OCA].  
1B03 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B03 OCA].  


==Reference==
==Reference==
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[[Category: Zvi, A.]]
[[Category: Zvi, A.]]
[[Category: P1053 structure]]
[[Category: P1053 structure]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:54:06 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:57:15 2008''

Revision as of 14:57, 30 June 2008

File:1b03.png

Template:STRUCTURE 1b03

SOLUTION STRUCTURE OF THE ANTIBODY-BOUND HIV-1IIIB V3 PEPTIDE

Template:ABSTRACT PUBMED 10201400

About this Structure

1B03 is a Single protein structure. Full experimental information is available from OCA.

Reference

A cis proline turn linking two beta-hairpin strands in the solution structure of an antibody-bound HIV-1IIIB V3 peptide., Tugarinov V, Zvi A, Levy R, Anglister J, Nat Struct Biol. 1999 Apr;6(4):331-5. PMID:10201400

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