1b3p: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
Line 1: Line 1:
[[Image:1b3p.gif|left|200px]]
{{Seed}}
[[Image:1b3p.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1b3p|  PDB=1b3p  |  SCENE=  }}  
{{STRUCTURE_1b3p|  PDB=1b3p  |  SCENE=  }}  


'''5'-D(*GP*GP*AP*GP*GP*AP*T)-3''''
===5'-D(*GP*GP*AP*GP*GP*AP*T)-3'===




==Overview==
<!--
BACKGROUND: Triplet repeat sequences are of considerable biological importance as the expansion of such tandem arrays can lead to the onset of a range of human diseases. Such sequences can self-pair via mismatch alignments to form higher order structures that have the potential to cause replication blocks, followed by strand slippage and sequence expansion. The all-purine d(GGA)n triplet repeat sequence is of particular interest because purines can align via G.G, A.A and G.A mismatch formation. RESULTS: We have solved the structure of the uniformly 13C,15N-labeled d(G1-G2-A3-G4-G5-A6-T7) sequence in 10 mM Na+ solution. This sequence adopts a novel twofold-symmetric duplex fold where interlocked V-shaped arrowhead motifs are aligned solely via interstrand G1.G4, G2.G5 and A3.A6 mismatch formation. The tip of the arrowhead motif is centered about the p-A3-p step, and symmetry-related local parallel-stranded duplex domains are formed by the G1-G2-A3 and G4-G5-A6 segments of partner strands. CONCLUSIONS: The purine-rich (GGA)n triplet repeat sequence is dispersed throughout the eukaryotic genome. Several features of the arrowhead duplex motif for the (GGA)2 triplet repeat provide a unique scaffold for molecular recognition. These include the large localized bend in the sugar-phosphate backbones, the segmental parallel-stranded alignment of strands and the exposure of the Watson-Crick edges of several mismatched bases.
The line below this paragraph, {{ABSTRACT_PUBMED_10425682}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10425682 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_10425682}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B3P OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B3P OCA].  


==Reference==
==Reference==
Line 32: Line 36:
[[Category: Uniform 13c]]
[[Category: Uniform 13c]]
[[Category: V-shaped backbone]]
[[Category: V-shaped backbone]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:01:29 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:10:25 2008''

Revision as of 15:10, 30 June 2008

File:1b3p.png

Template:STRUCTURE 1b3p

5'-D(*GP*GP*AP*GP*GP*AP*T)-3'

Template:ABSTRACT PUBMED 10425682

About this Structure

Full experimental information is available from OCA.

Reference

Interlocked mismatch-aligned arrowhead DNA motifs., Kettani A, Bouaziz S, Skripkin E, Majumdar A, Wang W, Jones RA, Patel DJ, Structure. 1999 Jul 15;7(7):803-15. PMID:10425682

Page seeded by OCA on Mon Jun 30 18:10:25 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1b3p&oldid=575816"