1b8j: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:1b8j.gif|left|200px]]
{{Seed}}
[[Image:1b8j.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1b8j|  PDB=1b8j  |  SCENE=  }}  
{{STRUCTURE_1b8j|  PDB=1b8j  |  SCENE=  }}  


'''ALKALINE PHOSPHATASE COMPLEXED WITH VANADATE'''
===ALKALINE PHOSPHATASE COMPLEXED WITH VANADATE===




==Overview==
<!--
A high resolution crystal structure of Escherichia coli alkaline phosphatase in the presence of vanadate has been refined to 1.9 A resolution. The vanadate ion takes on a trigonal bipyramidal geometry and is covalently bound by the active site serine nucleophile. A coordinated water molecule occupies the axial position opposite the serine nucleophile, whereas the equatorial oxygen atoms of the vanadate ion are stabilized by interactions with both Arg-166 and the zinc metal ions of the active site. This structural complex supports the in-line displacement mechanism of phosphomonoester hydrolysis by alkaline phosphatase and provides a model for the proposed transition state in the enzyme-catalyzed reaction.
The line below this paragraph, {{ABSTRACT_PUBMED_10085061}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10085061 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_10085061}}


==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Phosphoric monoester]]
[[Category: Phosphoric monoester]]
[[Category: Vanadate]]
[[Category: Vanadate]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:12:15 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:33:45 2008''
Retrieved from "https://proteopedia.org/1b8j"