1b9w: Difference between revisions

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[[Image:1b9w.~~jpg~~|left|200px]]

[[Image:1b9w.png|left|200px]]

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~~'''~~C-TERMINAL MEROZOITE SURFACE PROTEIN 1 FROM PLASMODIUM CYNOMOLGI~~'''~~

===C-TERMINAL MEROZOITE SURFACE PROTEIN 1 FROM PLASMODIUM CYNOMOLGI===

~~==Overview==~~

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The ~~C-terminal proteolytic processing product of merozoite surface protein 1~~ (~~MSP1)~~ appears ~~essential for successful erythrocyte invasion by the malarial parasite, Plasmodium. We have determined the crystal structure~~ at 1.~~8 A resolution of a soluble baculovirus-recombinant form of the protein from P~~. ~~cynomolgi, which confers excellent protective efficacy in primate vaccination trials. The structure comprises two EGF-like domains~~, ~~and sequence comparisons strongly suggest that the same conformation~~ is present in all species of Plasmodium, including P. falciparum and P. vivax, which are pathogenic in man. In particular, conserved interdomain contacts between the two EGF modules should preserve the compact form of the ~~molecule in all species~~. ~~Implications of the crystal structure for anti~~-~~malarial vaccine development are discussed.~~

The line below this paragraph, {{ABSTRACT_PUBMED_10230398}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10230398 is the PubMed ID number.

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==About this Structure==

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[[Category: Msp-1]]

[[Category: Surface antigen]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 11~~:15:20 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:39:57 2008''

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-[[Image:1b9w.jpg|left|200px]]
+{{Seed}}
+[[Image:1b9w.png|left|200px]]
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 {{STRUCTURE_1b9w|  PDB=1b9w  |  SCENE=  }}
-'''C-TERMINAL MEROZOITE SURFACE PROTEIN 1 FROM PLASMODIUM CYNOMOLGI'''
+===C-TERMINAL MEROZOITE SURFACE PROTEIN 1 FROM PLASMODIUM CYNOMOLGI===
-==Overview==
+<!--
-The C-terminal proteolytic processing product of merozoite surface protein 1 (MSP1) appears essential for successful erythrocyte invasion by the malarial parasite, Plasmodium. We have determined the crystal structure at 1.8 A resolution of a soluble baculovirus-recombinant form of the protein from P. cynomolgi, which confers excellent protective efficacy in primate vaccination trials. The structure comprises two EGF-like domains, and sequence comparisons strongly suggest that the same conformation is present in all species of Plasmodium, including P. falciparum and P. vivax, which are pathogenic in man. In particular, conserved interdomain contacts between the two EGF modules should preserve the compact form of the molecule in all species. Implications of the crystal structure for anti-malarial vaccine development are discussed.
+The line below this paragraph, {{ABSTRACT_PUBMED_10230398}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10230398 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10230398}}
 ==About this Structure==
@@ Line 29: / Line 33: @@
 [[Category: Msp-1]]
 [[Category: Surface antigen]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:15:20 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:39:57 2008''