1bcm: Difference between revisions

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[[Image:1bcm.gif|left|200px]]
{{Seed}}
[[Image:1bcm.png|left|200px]]


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{{STRUCTURE_1bcm|  PDB=1bcm  |  SCENE=  }}  
{{STRUCTURE_1bcm|  PDB=1bcm  |  SCENE=  }}  


'''BACTERIOPHAGE MU TRANSPOSASE CORE DOMAIN WITH 2 MONOMERS PER ASYMMETRIC UNIT'''
===BACTERIOPHAGE MU TRANSPOSASE CORE DOMAIN WITH 2 MONOMERS PER ASYMMETRIC UNIT===




==Overview==
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The crystal structure of the core domain of bacteriophage Mu transposase, MuA, has been determined at 2.4 A resolution. The first of two subdomains contains the active site and, despite very limited sequence homology, exhibits a striking similarity to the core domain of HIV-1 integrase, which carries out a similar set of biochemical reactions. It also exhibits more limited similarity to other nucleases, RNase H and RuvC. The second, a beta barrel, connects to the first subdomain through several contacts. Three independent determinations of the monomer structure from two crystal forms all show the active site held in a similar, apparently inactive configuration. The enzymatic activity of MuA is known to be activated by formation of a DNA-bound tetramer of the protein. We propose that the connections between the two subdomains may be involved in the cross-talk between the active site and the other domains of the transposase that controls the activity of the protein.
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{{ABSTRACT_PUBMED_7628012}}


==About this Structure==
==About this Structure==
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[[Category: Integrase]]
[[Category: Integrase]]
[[Category: Polynucleotidyl transferase]]
[[Category: Polynucleotidyl transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:20:37 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:50:22 2008''

Revision as of 15:50, 30 June 2008

File:1bcm.png

Template:STRUCTURE 1bcm

BACTERIOPHAGE MU TRANSPOSASE CORE DOMAIN WITH 2 MONOMERS PER ASYMMETRIC UNIT

Template:ABSTRACT PUBMED 7628012

About this Structure

1BCM is a Single protein structure of sequence from Enterobacteria phage mu. Full crystallographic information is available from OCA.

Reference

Structure of the bacteriophage Mu transposase core: a common structural motif for DNA transposition and retroviral integration., Rice P, Mizuuchi K, Cell. 1995 Jul 28;82(2):209-20. PMID:7628012

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