1bd2: Difference between revisions

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[[Image:1bd2.~~gif~~|left|200px]]

[[Image:1bd2.png|left|200px]]

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~~'''~~COMPLEX BETWEEN HUMAN T-CELL RECEPTOR B7, VIRAL PEPTIDE (TAX) AND MHC CLASS I MOLECULE HLA-A 0201~~'''~~

===COMPLEX BETWEEN HUMAN T-CELL RECEPTOR B7, VIRAL PEPTIDE (TAX) AND MHC CLASS I MOLECULE HLA-A 0201===

~~==Overview==~~

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The ~~three-dimensional structure of a human alphabeta T cell receptor (TCR)~~, B7, ~~bound~~ to the ~~HLA-A2 molecule~~/~~HTLV-1 Tax peptide complex was determined by x-ray crystallography~~. Although different from the A6 TCR, previously studied, in 16 of the 17 residues that contact HLA-A2/Tax, the B7 TCR binds in a similar diagonal manner, only slightly tipped and rotated, relative to the A6 TCR. ~~The structure explains data from functional assays on the specificity differences between the B7 and A6 TCRs for agonist~~, ~~partial agonist, and null peptides. The existence of a structurally similar diagonal binding mode for TCRs favors mechanisms based on~~ the ~~formation of geometrically defined supramolecular assemblies for initiating signaling~~.

The line below this paragraph, {{ABSTRACT_PUBMED_9586631}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 9586631 is the PubMed ID number.

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==About this Structure==

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[[Category: Utz, U.]]

[[Category: Wiley, D C.]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 11~~:21:30 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:52:16 2008''

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-[[Image:1bd2.gif|left|200px]]
+{{Seed}}
+[[Image:1bd2.png|left|200px]]
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 {{STRUCTURE_1bd2|  PDB=1bd2  |  SCENE=  }}
-'''COMPLEX BETWEEN HUMAN T-CELL RECEPTOR B7, VIRAL PEPTIDE (TAX) AND MHC CLASS I MOLECULE HLA-A 0201'''
+===COMPLEX BETWEEN HUMAN T-CELL RECEPTOR B7, VIRAL PEPTIDE (TAX) AND MHC CLASS I MOLECULE HLA-A 0201===
-==Overview==
+<!--
-The three-dimensional structure of a human alphabeta T cell receptor (TCR), B7, bound to the HLA-A2 molecule/HTLV-1 Tax peptide complex was determined by x-ray crystallography. Although different from the A6 TCR, previously studied, in 16 of the 17 residues that contact HLA-A2/Tax, the B7 TCR binds in a similar diagonal manner, only slightly tipped and rotated, relative to the A6 TCR. The structure explains data from functional assays on the specificity differences between the B7 and A6 TCRs for agonist, partial agonist, and null peptides. The existence of a structurally similar diagonal binding mode for TCRs favors mechanisms based on the formation of geometrically defined supramolecular assemblies for initiating signaling.
+The line below this paragraph, {{ABSTRACT_PUBMED_9586631}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9586631 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9586631}}
 ==About this Structure==
@@ Line 29: / Line 33: @@
 [[Category: Utz, U.]]
 [[Category: Wiley, D C.]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:21:30 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:52:16 2008''