1bf0: Difference between revisions

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[[Image:1bf0.gif|left|200px]]
{{Seed}}
[[Image:1bf0.png|left|200px]]


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{{STRUCTURE_1bf0|  PDB=1bf0  |  SCENE=  }}  
{{STRUCTURE_1bf0|  PDB=1bf0  |  SCENE=  }}  


'''CALCICLUDINE (CAC) FROM GREEN MAMBA DENDROASPIS ANGUSTICEPS, NMR, 15 STRUCTURES'''
===CALCICLUDINE (CAC) FROM GREEN MAMBA DENDROASPIS ANGUSTICEPS, NMR, 15 STRUCTURES===




==Overview==
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Calcicludine, a 60-amino acid protein isolated from the green mamba venom, has been recently identified as blocking a large set (i.e., L-, N- and P-type) of Ca2+ channels. The three-dimensional structure of calcicludine has been determined by NMR and molecular modeling using a data set of 723 unambiguous and 265 ambiguous distance restraints, as 33 phi and 13 chi1 dihedral angle restraints. Analysis of the 15 final structures (backbone root-mean-square deviation = 0.6 A) shows that calcicludine adopts the Kunitz-type protease inhibitor fold. Its three-dimensional structure is similar to that of snake K+ channel blockers dendrotoxins. Conformational differences with protease inhibitors and dendrotoxins are localized in the 3(10) helix and loop 1 (segments 1-7 and 10-19), the extremity of the beta-hairpin (segment 27-30), and loop 2 (segment 39-44). These regions correspond to the functional sites of bovine pancreatic trypsin inhibitor (BPTI) and dendrotoxins. The positioning of the N-terminal segment 1-7 relative to the rest of the protein is characteristic of calcicludine. The involvement of this segment and the positively charged K31 at the tip of the beta-hairpin in the biological activity of calcicludine is discussed.
The line below this paragraph, {{ABSTRACT_PUBMED_10081964}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_10081964}}


==About this Structure==
==About this Structure==
1BF0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dendroaspis_angusticeps Dendroaspis angusticeps]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BF0 OCA].  
1BF0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dendroaspis_angusticeps Dendroaspis angusticeps]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BF0 OCA].  


==Reference==
==Reference==
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[[Category: Zinn-Justin, S.]]
[[Category: Zinn-Justin, S.]]
[[Category: Calcium channel blocker]]
[[Category: Calcium channel blocker]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:25:53 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:00:46 2008''

Revision as of 16:00, 30 June 2008

File:1bf0.png

Template:STRUCTURE 1bf0

CALCICLUDINE (CAC) FROM GREEN MAMBA DENDROASPIS ANGUSTICEPS, NMR, 15 STRUCTURES

Template:ABSTRACT PUBMED 10081964

About this Structure

1BF0 is a Single protein structure of sequence from Dendroaspis angusticeps. Full experimental information is available from OCA.

Reference

Conformational and functional variability supported by the BPTI fold: solution structure of the Ca2+ channel blocker calcicludine., Gilquin B, Lecoq A, Desne F, Guenneugues M, Zinn-Justin S, Menez A, Proteins. 1999 Mar 1;34(4):520-32. PMID:10081964

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