1bfe: Difference between revisions

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~~'''~~THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95~~'''~~

===THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95===

~~==Overview==~~

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~~Modular PDZ domains~~, ~~found in many cell junction-associated proteins~~, ~~mediate~~ the ~~clustering of membrane ion channels by binding~~ to ~~their C-terminus. The X-ray crystallographic structures of~~ the ~~third PDZ domain from the synaptic protein PSD-95 in complex with and in the absence of its peptide ligand have been determined~~ at 1.~~8 angstroms and 2~~.~~3 angstroms resolution~~, ~~respectively. The structures reveal that a four-residue C-terminal stretch (X-Thr/Ser-X-Val-COO(-)) engages the PDZ domain through antiparallel main chain interactions with a beta sheet of~~ the ~~domain~~. ~~Recognition of the terminal carboxylate group of the peptide is conferred by a cradle of main chain amides provided by a Gly~~-~~Leu~~-~~Gly-Phe loop as well as by an arginine side chain. Specific side chain interactions and a prominent hydrophobic pocket explain the selective recognition of the C-terminal consensus sequence.~~

The line below this paragraph, {{ABSTRACT_PUBMED_8674113}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 8674113 is the PubMed ID number.

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==About this Structure==

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[[Category: Peptide recognition]]

[[Category: Protein localization]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 11~~:26:37 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:02:17 2008''

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-[[Image:1bfe.gif|left|200px]]
+{{Seed}}
+[[Image:1bfe.png|left|200px]]
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 {{STRUCTURE_1bfe|  PDB=1bfe  |  SCENE=  }}
-'''THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95'''
+===THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95===
-==Overview==
+<!--
-Modular PDZ domains, found in many cell junction-associated proteins, mediate the clustering of membrane ion channels by binding to their C-terminus. The X-ray crystallographic structures of the third PDZ domain from the synaptic protein PSD-95 in complex with and in the absence of its peptide ligand have been determined at 1.8 angstroms and 2.3 angstroms resolution, respectively. The structures reveal that a four-residue C-terminal stretch (X-Thr/Ser-X-Val-COO(-)) engages the PDZ domain through antiparallel main chain interactions with a beta sheet of the domain. Recognition of the terminal carboxylate group of the peptide is conferred by a cradle of main chain amides provided by a Gly-Leu-Gly-Phe loop as well as by an arginine side chain. Specific side chain interactions and a prominent hydrophobic pocket explain the selective recognition of the C-terminal consensus sequence.
+The line below this paragraph, {{ABSTRACT_PUBMED_8674113}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 8674113 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_8674113}}
 ==About this Structure==
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 [[Category: Peptide recognition]]
 [[Category: Protein localization]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:26:37 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:02:17 2008''