1bg7: Difference between revisions

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[[Image:1bg7.~~gif~~|left|200px]]

[[Image:1bg7.png|left|200px]]

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~~'''~~LOCALIZED UNFOLDING AT THE JUNCTION OF THREE FERRITIN SUBUNITS. A MECHANISM FOR IRON RELEASE?~~'''~~

===LOCALIZED UNFOLDING AT THE JUNCTION OF THREE FERRITIN SUBUNITS. A MECHANISM FOR IRON RELEASE?===

~~==Overview==~~

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~~How and where iron exits from ferritin for cellular use is unknown. Twenty-four protein subunits create a cavity in ferritin where iron is concentrated >10~~(~~11)-fold~~ as ~~a mineral~~. ~~Proline substitution for conserved leucine 134 (L134P~~) ~~allowed normal assembly but increased iron exit rates~~. X-~~ray crystallography of H~~-L134P ferritin revealed localized unfolding at the 3-fold axis, also iron entry sites, consistent with shared use sites for iron exit and entry. The junction of three ferritin subunits appears to be a dynamic aperture with a "shutter" that cytoplasmic factors might open or close to regulate iron release in vivo.

The line below this paragraph, {{ABSTRACT_PUBMED_9668036}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 9668036 is the PubMed ID number.

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==About this Structure==

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[[Category: Ferritin]]

[[Category: Iron storage]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 11~~:28:24 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:05:45 2008''

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-[[Image:1bg7.gif|left|200px]]
+{{Seed}}
+[[Image:1bg7.png|left|200px]]
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@@ Line 9: / Line 10: @@
 {{STRUCTURE_1bg7|  PDB=1bg7  |  SCENE=  }}
-'''LOCALIZED UNFOLDING AT THE JUNCTION OF THREE FERRITIN SUBUNITS. A MECHANISM FOR IRON RELEASE?'''
+===LOCALIZED UNFOLDING AT THE JUNCTION OF THREE FERRITIN SUBUNITS. A MECHANISM FOR IRON RELEASE?===
-==Overview==
+<!--
-How and where iron exits from ferritin for cellular use is unknown. Twenty-four protein subunits create a cavity in ferritin where iron is concentrated &gt;10(11)-fold as a mineral. Proline substitution for conserved leucine 134 (L134P) allowed normal assembly but increased iron exit rates. X-ray crystallography of H-L134P ferritin revealed localized unfolding at the 3-fold axis, also iron entry sites, consistent with shared use sites for iron exit and entry. The junction of three ferritin subunits appears to be a dynamic aperture with a "shutter" that cytoplasmic factors might open or close to regulate iron release in vivo.
+The line below this paragraph, {{ABSTRACT_PUBMED_9668036}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9668036 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9668036}}
 ==About this Structure==
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 [[Category: Ferritin]]
 [[Category: Iron storage]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:28:24 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:05:45 2008''