1bil: Difference between revisions

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[[Image:1bil.jpg|left|200px]]
{{Seed}}
[[Image:1bil.png|left|200px]]


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{{STRUCTURE_1bil|  PDB=1bil  |  SCENE=  }}  
{{STRUCTURE_1bil|  PDB=1bil  |  SCENE=  }}  


'''CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS'''
===CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS===




==Overview==
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The binding modes of three peptidomimetic P2-P3 butanediamide renin inhibitors have been determined by x-ray crystallography. The inhibitors are bound with their backbones in an extended conformation, and their side chains occupying the S5 to S1' pockets. A (2-amino-4-thiazolyl)methyl side chain at the P2 position shows stronger hydrogen-bonding and van der Waals interactions with renin than the His side chain, which is present in the natural substrate. The ACHPA-gamma-lactam transition state analog has similar interactions with renin as the dihydroxyethylene transition state analog.
The line below this paragraph, {{ABSTRACT_PUBMED_7493993}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 7493993 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7493993}}


==About this Structure==
==About this Structure==
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[[Category: Tong, L.]]
[[Category: Tong, L.]]
[[Category: Aspartic proteinase]]
[[Category: Aspartic proteinase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:33:35 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:13:22 2008''

Revision as of 16:13, 30 June 2008

File:1bil.png

Template:STRUCTURE 1bil

CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS

Template:ABSTRACT PUBMED 7493993

About this Structure

1BIL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystallographic studies on the binding modes of P2-P3 butanediamide renin inhibitors., Tong L, Pav S, Lamarre D, Simoneau B, Lavallee P, Jung G, J Biol Chem. 1995 Dec 8;270(49):29520-4. PMID:7493993

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