1bob: Difference between revisions

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[[Image:1bob.jpg|left|200px]]
{{Seed}}
[[Image:1bob.png|left|200px]]


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{{STRUCTURE_1bob|  PDB=1bob  |  SCENE=  }}  
{{STRUCTURE_1bob|  PDB=1bob  |  SCENE=  }}  


'''HISTONE ACETYLTRANSFERASE HAT1 FROM SACCHAROMYCES CEREVISIAE IN COMPLEX WITH ACETYL COENZYME A'''
===HISTONE ACETYLTRANSFERASE HAT1 FROM SACCHAROMYCES CEREVISIAE IN COMPLEX WITH ACETYL COENZYME A===




==Overview==
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We have solved the crystal structure of the yeast histone acetyltransferase Hat1-acetyl coenzyme A (AcCoA) complex at 2.3 A resolution. Hat1 has an elongated, curved structure, and the AcCoA molecule is bound in a cleft on the concave surface of the protein, marking the active site of the enzyme. A channel of variable width and depth that runs across the protein is probably the binding site for the histone substrate. A model for histone H4 binding by Hat1 is discussed in terms of possible sources of specific lysine recognition by the enzyme. The structure of Hat1 provides a model for the structures of the catalytic domains of a protein superfamily that includes other histone acetyltransferases such as Gcn5 and CBP.
The line below this paragraph, {{ABSTRACT_PUBMED_9727486}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9727486 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9727486}}


==About this Structure==
==About this Structure==
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[[Category: Histone acetyltransferase]]
[[Category: Histone acetyltransferase]]
[[Category: Histone modification]]
[[Category: Histone modification]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:45:45 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:27:18 2008''

Revision as of 16:27, 30 June 2008

File:1bob.png

Template:STRUCTURE 1bob

HISTONE ACETYLTRANSFERASE HAT1 FROM SACCHAROMYCES CEREVISIAE IN COMPLEX WITH ACETYL COENZYME A

Template:ABSTRACT PUBMED 9727486

About this Structure

1BOB is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure of the histone acetyltransferase Hat1: a paradigm for the GCN5-related N-acetyltransferase superfamily., Dutnall RN, Tafrov ST, Sternglanz R, Ramakrishnan V, Cell. 1998 Aug 21;94(4):427-38. PMID:9727486

Page seeded by OCA on Mon Jun 30 19:27:18 2008

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