1bp7: Difference between revisions

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[[Image:1bp7.gif|left|200px]]
{{Seed}}
[[Image:1bp7.png|left|200px]]


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{{STRUCTURE_1bp7|  PDB=1bp7  |  SCENE=  }}  
{{STRUCTURE_1bp7|  PDB=1bp7  |  SCENE=  }}  


'''GROUP I MOBILE INTRON ENDONUCLEASE I-CREI COMPLEXED WITH HOMING SITE DNA'''
===GROUP I MOBILE INTRON ENDONUCLEASE I-CREI COMPLEXED WITH HOMING SITE DNA===




==Overview==
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The structure of the LAGLIDADG intron-encoded homing endonuclease I-CreI bound to homing site DNA has been determined. The interface is formed by an extended, concave beta sheet from each enzyme monomer that contacts each DNA half-site, resulting in direct side-chain contacts to 18 of the 24 base pairs across the full-length homing site. The structure indicates that I-CreI is optimized to its role in genetic transposition by exhibiting long site-recognition while being able to cleave many closely related target sequences. DNA cleavage is mediated by a compact pair of active sites in the I-CreI homodimer, each of which contains a separate bound divalent cation.
The line below this paragraph, {{ABSTRACT_PUBMED_9809068}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9809068 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9809068}}


==About this Structure==
==About this Structure==
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[[Category: Intron homing]]
[[Category: Intron homing]]
[[Category: Laglidadg motif]]
[[Category: Laglidadg motif]]
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