1bt6: Difference between revisions

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[[Image:1bt6.~~jpg~~|left|200px]]

[[Image:1bt6.png|left|200px]]

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~~'''~~P11 (S100A10), LIGAND OF ANNEXIN II IN COMPLEX WITH ANNEXIN II N-TERMINUS~~'''~~

===P11 (S100A10), LIGAND OF ANNEXIN II IN COMPLEX WITH ANNEXIN II N-TERMINUS===

~~==Overview==~~

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The ~~aggregation and membrane fusion properties of annexin II are modulated by the association with a regulatory light chain called p11.p11 is a member of the S100 EF-hand protein family~~, ~~which is unique in having lost its calcium-binding properties. We report~~ the ~~first structure of a complex between p11 and its cognate peptide,~~ the ~~N-terminus of annexin II,~~ as ~~well as that of p11 alone~~. ~~The basic unit for p11~~ is ~~a tight, non-covalent dimer. In~~ the ~~complex, each annexin II peptide forms hydrophobic interactions with both p11 monomers, thus providing a structural basis for high affinity interactions between an S100 protein and its target sequence~~. ~~Finally, p11 forms a disulfide~~-~~linked tetramer in both types of crystals thus suggesting a model for an oxidized form of other S100 proteins that have been found in the extracellular milieu.~~

The line below this paragraph, {{ABSTRACT_PUBMED_9886297}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 9886297 is the PubMed ID number.

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==About this Structure==

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[[Category: Ligand of annexin ii]]

[[Category: S100 family]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 11~~:55:48 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:41:05 2008''

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-[[Image:1bt6.jpg|left|200px]]
+{{Seed}}
+[[Image:1bt6.png|left|200px]]
 <!--
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 {{STRUCTURE_1bt6|  PDB=1bt6  |  SCENE=  }}
-'''P11 (S100A10), LIGAND OF ANNEXIN II IN COMPLEX WITH ANNEXIN II N-TERMINUS'''
+===P11 (S100A10), LIGAND OF ANNEXIN II IN COMPLEX WITH ANNEXIN II N-TERMINUS===
-==Overview==
+<!--
-The aggregation and membrane fusion properties of annexin II are modulated by the association with a regulatory light chain called p11.p11 is a member of the S100 EF-hand protein family, which is unique in having lost its calcium-binding properties. We report the first structure of a complex between p11 and its cognate peptide, the N-terminus of annexin II, as well as that of p11 alone. The basic unit for p11 is a tight, non-covalent dimer. In the complex, each annexin II peptide forms hydrophobic interactions with both p11 monomers, thus providing a structural basis for high affinity interactions between an S100 protein and its target sequence. Finally, p11 forms a disulfide-linked tetramer in both types of crystals thus suggesting a model for an oxidized form of other S100 proteins that have been found in the extracellular milieu.
+The line below this paragraph, {{ABSTRACT_PUBMED_9886297}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9886297 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9886297}}
 ==About this Structure==
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 [[Category: Ligand of annexin ii]]
 [[Category: S100 family]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:55:48 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:41:05 2008''