1bt7: Difference between revisions

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[[Image:1bt7.gif|left|200px]]
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[[Image:1bt7.png|left|200px]]


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{{STRUCTURE_1bt7|  PDB=1bt7  |  SCENE=  }}  
{{STRUCTURE_1bt7|  PDB=1bt7  |  SCENE=  }}  


'''THE SOLUTION NMR STRUCTURE OF THE N-TERMINAL PROTEASE DOMAIN OF THE HEPATITIS C VIRUS (HCV) NS3-PROTEIN, FROM BK STRAIN, 20 STRUCTURES'''
===THE SOLUTION NMR STRUCTURE OF THE N-TERMINAL PROTEASE DOMAIN OF THE HEPATITIS C VIRUS (HCV) NS3-PROTEIN, FROM BK STRAIN, 20 STRUCTURES===




==Overview==
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The solution structure of the hepatitis C virus (BK strain) NS3 protein N-terminal domain (186 residues) has been solved by NMR spectroscopy. The protein is a serine protease with a chymotrypsin-type fold, and is involved in the maturation of the viral polyprotein. Despite the knowledge that its activity is enhanced by the action of a viral protein cofactor, NS4A, the mechanism of activation is not yet clear. The analysis of the folding in solution and the differences from the crystallographic structures allow the formulation of a model in which, in addition to the NS4A cofactor, the substrate plays an important role in the activation of the catalytic mechanism. A unique structural feature is the presence of a zinc-binding site exposed on the surface, subject to a slow conformational exchange process.
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{{ABSTRACT_PUBMED_10366511}}


==About this Structure==
==About this Structure==
1BT7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BT7 OCA].  
1BT7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BT7 OCA].  


==Reference==
==Reference==
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[[Category: Serine protease]]
[[Category: Serine protease]]
[[Category: Viral non-structural protein]]
[[Category: Viral non-structural protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:55:48 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:41:10 2008''

Revision as of 16:41, 30 June 2008

File:1bt7.png

Template:STRUCTURE 1bt7

THE SOLUTION NMR STRUCTURE OF THE N-TERMINAL PROTEASE DOMAIN OF THE HEPATITIS C VIRUS (HCV) NS3-PROTEIN, FROM BK STRAIN, 20 STRUCTURES

Template:ABSTRACT PUBMED 10366511

About this Structure

1BT7 is a Single protein structure of sequence from Hepatitis c virus. Full experimental information is available from OCA.

Reference

The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism., Barbato G, Cicero DO, Nardi MC, Steinkuhler C, Cortese R, De Francesco R, Bazzo R, J Mol Biol. 1999 Jun 4;289(2):371-84. PMID:10366511

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