1buh: Difference between revisions

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[[Image:1buh.gif|left|200px]]
{{Seed}}
[[Image:1buh.png|left|200px]]


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{{STRUCTURE_1buh|  PDB=1buh  |  SCENE=  }}  
{{STRUCTURE_1buh|  PDB=1buh  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF THE HUMAN CDK2 KINASE COMPLEX WITH CELL CYCLE-REGULATORY PROTEIN CKSHS1'''
===CRYSTAL STRUCTURE OF THE HUMAN CDK2 KINASE COMPLEX WITH CELL CYCLE-REGULATORY PROTEIN CKSHS1===




==Overview==
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The 2.6 Angstrom crystal structure for human cyclin-dependent kinase 2(CDK2) in complex with CksHs1, a human homolog of essential yeast cell cycle-regulatory proteins suc1 and Cks1, reveals that CksHs1 binds via all four beta strands to the kinase C-terminal lobe. This interface is biologically critical, based upon mutational analysis, but far from the CDK2 N-terminal lobe, cyclin, and regulatory phosphorylation sites. CDK2 binds the Cks single domain conformation and interacts with conserved hydrophobic residues plus His-60 and Glu-63 in their closed beta-hinge motif conformation. The beta hinge opening to form the Cks beta-interchanged dimer sterically precludes CDK2 binding, providing a possible mechanism regulating CDK2-Cks interactions. One face of the complex exposes the sequence-conserved phosphate-binding region on Cks and the ATP-binding site on CDK2, suggesting that CKs may target CDK2 to other phosphoproteins during the cell cycle.
The line below this paragraph, {{ABSTRACT_PUBMED_8601310}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 8601310 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8601310}}


==About this Structure==
==About this Structure==
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[[Category: Tainer, J A.]]
[[Category: Tainer, J A.]]
[[Category: Transferase]]
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:58:14 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:44:26 2008''

Revision as of 16:44, 30 June 2008

File:1buh.png

Template:STRUCTURE 1buh

CRYSTAL STRUCTURE OF THE HUMAN CDK2 KINASE COMPLEX WITH CELL CYCLE-REGULATORY PROTEIN CKSHS1

Template:ABSTRACT PUBMED 8601310

About this Structure

1BUH is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1., Bourne Y, Watson MH, Hickey MJ, Holmes W, Rocque W, Reed SI, Tainer JA, Cell. 1996 Mar 22;84(6):863-74. PMID:8601310

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