1bvk: Difference between revisions

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[[Image:1bvk.~~gif~~|left|200px]]

[[Image:1bvk.png|left|200px]]

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~~'''~~HUMANIZED ANTI-LYSOZYME FV COMPLEXED WITH LYSOZYME~~'''~~

===HUMANIZED ANTI-LYSOZYME FV COMPLEXED WITH LYSOZYME===

~~==Overview==~~

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The ~~crystal structure of the complex between hen egg lysozyme and the Fv fragment of a humanized antilysozyme antibody was determined to 2.7-A resolution. The structure of~~ the ~~antigen combining site in the complex is nearly identical~~ to ~~that of~~ the ~~complexed form of the parent mouse antibody, D1~~.3. ~~In contrast~~, the combining sites of the unliganded mouse and humanized antilysozymes show moderate conformational differences. This disparity suggests that a conformational readjustment process linked to antigen binding reverses adverse conformations in the complementarity determining regions that had been introduced by engineering these segments next to human framework regions in the humanized antibody.

The line below this paragraph, {{ABSTRACT_PUBMED_9463398}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 9463398 is the PubMed ID number.

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==About this Structure==

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[[Category: Fv]]

[[Category: Humanized antibody]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 12~~:00:24 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:47:12 2008''

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-[[Image:1bvk.gif|left|200px]]
+{{Seed}}
+[[Image:1bvk.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1bvk|  PDB=1bvk  |  SCENE=  }}
-'''HUMANIZED ANTI-LYSOZYME FV COMPLEXED WITH LYSOZYME'''
+===HUMANIZED ANTI-LYSOZYME FV COMPLEXED WITH LYSOZYME===
-==Overview==
+<!--
-The crystal structure of the complex between hen egg lysozyme and the Fv fragment of a humanized antilysozyme antibody was determined to 2.7-A resolution. The structure of the antigen combining site in the complex is nearly identical to that of the complexed form of the parent mouse antibody, D1.3. In contrast, the combining sites of the unliganded mouse and humanized antilysozymes show moderate conformational differences. This disparity suggests that a conformational readjustment process linked to antigen binding reverses adverse conformations in the complementarity determining regions that had been introduced by engineering these segments next to human framework regions in the humanized antibody.
+The line below this paragraph, {{ABSTRACT_PUBMED_9463398}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9463398 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9463398}}
 ==About this Structure==
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 [[Category: Fv]]
 [[Category: Humanized antibody]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:00:24 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:47:12 2008''