1bw6: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
Line 1: Line 1:
[[Image:1bw6.gif|left|200px]]
{{Seed}}
[[Image:1bw6.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1bw6|  PDB=1bw6  |  SCENE=  }}  
{{STRUCTURE_1bw6|  PDB=1bw6  |  SCENE=  }}  


'''HUMAN CENTROMERE PROTEIN B (CENP-B) DNA BINDIGN DOMAIN RP1'''
===HUMAN CENTROMERE PROTEIN B (CENP-B) DNA BINDIGN DOMAIN RP1===




==Overview==
<!--
CENP-B has been suggested to organize arrays of centromere satellite DNA into a higher order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes. The N-terminal portion of CENP-B is a 15 kDa DNA binding domain (DBD) consisting of two repeating units, RP1 and RP2. The DBD specifically binds to the CENP-B box sequence (17 bp) in centromere DNA. We determined the solution structure of human CENP-B DBD RP1 by multi-dimensional 1H, 13C and 15N NMR methods. The CENP-B DBD RP1 structure consists of four helices and has a helix-turn-helix structure. The overall folding is similar to those of some other eukaryotic DBDs, although significant sequence homology with these proteins was not found. The DBD of yeast RAP1, a telomere binding protein, is most similar to CENP-B DBD RP1. We studied the interaction between CENP-B DBD RP1 and the CENP-B box by the use of NMR chemical shift perturbation. The results suggest that CENP-B DBD RP1 interacts with one of the essential regions of the CENP-B box DNA, mainly at the N-terminal basic region, the N-terminal portion of helix 2 and helix 3.
The line below this paragraph, {{ABSTRACT_PUBMED_9451007}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9451007 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_9451007}}


==About this Structure==
==About this Structure==
1BW6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BW6 OCA].  
1BW6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BW6 OCA].  


==Reference==
==Reference==
Line 35: Line 39:
[[Category: Rsgi]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:01:37 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:48:43 2008''

Revision as of 16:48, 30 June 2008

File:1bw6.png

Template:STRUCTURE 1bw6

HUMAN CENTROMERE PROTEIN B (CENP-B) DNA BINDIGN DOMAIN RP1

Template:ABSTRACT PUBMED 9451007

About this Structure

1BW6 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

A helix-turn-helix structure unit in human centromere protein B (CENP-B)., Iwahara J, Kigawa T, Kitagawa K, Masumoto H, Okazaki T, Yokoyama S, EMBO J. 1998 Feb 2;17(3):827-37. PMID:9451007

Page seeded by OCA on Mon Jun 30 19:48:43 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1bw6&oldid=579806"