1bw8: Difference between revisions

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[[Image:1bw8.~~gif~~|left|200px]]

[[Image:1bw8.png|left|200px]]

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~~'''~~MU2 ADAPTIN SUBUNIT (AP50) OF AP2 ADAPTOR (SECOND DOMAIN), COMPLEXED WITH EGFR INTERNALIZATION PEPTIDE FYRALM~~'''~~

===MU2 ADAPTIN SUBUNIT (AP50) OF AP2 ADAPTOR (SECOND DOMAIN), COMPLEXED WITH EGFR INTERNALIZATION PEPTIDE FYRALM===

~~==Overview==~~

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~~Many cell surface proteins are marked for endocytosis by a cytoplasmic sequence motif~~, ~~tyrosine-X-X-(hydrophobic residue)~~, ~~that is recognized by~~ the ~~mu2 subunit of AP2 adaptors. Crystal structures of~~ the ~~internalization signal binding domain of mu2 complexed with the internalization signal peptides of epidermal growth factor receptor and the trans-Golgi network protein TGN38 have been determined~~ at 2.~~7 angstrom resolution~~. The signal peptides adopted an extended conformation rather than the expected tight turn. Specificity was conferred by hydrophobic pockets that bind the tyrosine and leucine in the peptide. In the crystal, the ~~protein forms dimers that could increase the strength and specificity of binding to dimeric receptors~~.

The line below this paragraph, {{ABSTRACT_PUBMED_9812899}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 9812899 is the PubMed ID number.

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==About this Structure==

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[[Category: Endocytosis]]

[[Category: Peptide complex]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 12~~:01:48 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:48:55 2008''

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-[[Image:1bw8.gif|left|200px]]
+{{Seed}}
+[[Image:1bw8.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1bw8|  PDB=1bw8  |  SCENE=  }}
-'''MU2 ADAPTIN SUBUNIT (AP50) OF AP2 ADAPTOR (SECOND DOMAIN), COMPLEXED WITH EGFR INTERNALIZATION PEPTIDE FYRALM'''
+===MU2 ADAPTIN SUBUNIT (AP50) OF AP2 ADAPTOR (SECOND DOMAIN), COMPLEXED WITH EGFR INTERNALIZATION PEPTIDE FYRALM===
-==Overview==
+<!--
-Many cell surface proteins are marked for endocytosis by a cytoplasmic sequence motif, tyrosine-X-X-(hydrophobic residue), that is recognized by the mu2 subunit of AP2 adaptors. Crystal structures of the internalization signal binding domain of mu2 complexed with the internalization signal peptides of epidermal growth factor receptor and the trans-Golgi network protein TGN38 have been determined at 2.7 angstrom resolution. The signal peptides adopted an extended conformation rather than the expected tight turn. Specificity was conferred by hydrophobic pockets that bind the tyrosine and leucine in the peptide. In the crystal, the protein forms dimers that could increase the strength and specificity of binding to dimeric receptors.
+The line below this paragraph, {{ABSTRACT_PUBMED_9812899}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9812899 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9812899}}
 ==About this Structure==
@@ Line 27: / Line 31: @@
 [[Category: Endocytosis]]
 [[Category: Peptide complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:01:48 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:48:55 2008''