1bys: Difference between revisions

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[[Image:1bys.jpg|left|200px]]
{{Seed}}
[[Image:1bys.png|left|200px]]


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{{STRUCTURE_1bys|  PDB=1bys  |  SCENE=  }}  
{{STRUCTURE_1bys|  PDB=1bys  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF NUC COMPLEXED WITH TUNGSTATE'''
===CRYSTAL STRUCTURE OF NUC COMPLEXED WITH TUNGSTATE===




==Overview==
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The first crystal structure of a phospholipase D (PLD) family member has been determined at 2.0 A resolution. The PLD superfamily is defined by a common sequence motif, HxK(x)4D(x)6GSxN, and includes enzymes involved in signal transduction, lipid biosynthesis, endonucleases and open reading frames in pathogenic viruses and bacteria. The crystal structure suggests that residues from two sequence motifs form a single active site. A histidine residue from one motif acts as a nucleophile in the catalytic mechanism, forming a phosphoenzyme intermediate, whereas a histidine residue from the other motif appears to function as a general acid in the cleavage of the phosphodiester bond. The structure suggests that the conserved lysine residues are involved in phosphate binding. Large-scale genomic sequencing revealed that there are many PLD family members. Our results suggest that all of these proteins may possess a common structure and catalytic mechanism.
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{{ABSTRACT_PUBMED_10074947}}


==About this Structure==
==About this Structure==
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[[Category: Endonuclease]]
[[Category: Endonuclease]]
[[Category: Phosphodiesterase]]
[[Category: Phosphodiesterase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:07:45 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:57:58 2008''

Revision as of 16:58, 30 June 2008

File:1bys.png

Template:STRUCTURE 1bys

CRYSTAL STRUCTURE OF NUC COMPLEXED WITH TUNGSTATE

Template:ABSTRACT PUBMED 10074947

About this Structure

1BYS is a Single protein structure of sequence from Salmonella typhimurium. Full crystallographic information is available from OCA.

Reference

Crystal structure of a phospholipase D family member., Stuckey JA, Dixon JE, Nat Struct Biol. 1999 Mar;6(3):278-84. PMID:10074947

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