1bzy: Difference between revisions

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[[Image:1bzy.gif|left|200px]]
{{Seed}}
[[Image:1bzy.png|left|200px]]


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{{STRUCTURE_1bzy|  PDB=1bzy  |  SCENE=  }}  
{{STRUCTURE_1bzy|  PDB=1bzy  |  SCENE=  }}  


'''HUMAN HGPRTASE WITH TRANSITION STATE INHIBITOR'''
===HUMAN HGPRTASE WITH TRANSITION STATE INHIBITOR===




==Overview==
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The structure of human HGPRT bound to the transition-state analog immucillinGP and Mg2+-pyrophosphate has been determined to 2.0 A resolution. ImmucillinGP was designed as a stable analog with the stereoelectronic features of the transition state. Bound inhibitor at the catalytic site indicates that the oxocarbenium ion of the transition state is stabilized by neighboring-group participation from MgPPi and O5'. A short hydrogen bond forms between Asp 137 and the purine ring analog. Two Mg2+ ions sandwich the pyrophosphate and contact both hydroxyls of the ribosyl analog. The transition-state analog is shielded from bulk solvent by a catalytic loop that moves approximately 25 A to cover the active site and becomes an ordered antiparallel beta-sheet.
The line below this paragraph, {{ABSTRACT_PUBMED_10360366}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_10360366}}


==About this Structure==
==About this Structure==
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[[Category: Pyrophosphate]]
[[Category: Pyrophosphate]]
[[Category: Transition state]]
[[Category: Transition state]]
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