1c0t: Difference between revisions

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[[Image:1c0t.gif|left|200px]]
{{Seed}}
[[Image:1c0t.png|left|200px]]


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{{STRUCTURE_1c0t|  PDB=1c0t  |  SCENE=  }}  
{{STRUCTURE_1c0t|  PDB=1c0t  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH BM+21.1326'''
===CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH BM+21.1326===




==Overview==
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We have determined the crystal structures of thiazoloisoindolinone non-nucleoside inhibitors in complex with HIV-1 reverse transcriptase to high-resolution limits of 2.7 A (BM +21.1326) and 2. 52 A (BM +50.0934). We find that the binding modes of this series of inhibitors closely resemble that of "two-ring" non-nucleoside reverse transcriptase inhibitors. The structures allow rationalization of stereochemical requirements, structure-activity data, and drug resistance data. Comparisons with our previous structures suggest modifications to the inhibitors that might improve resilience to drug-resistant mutant forms of reverse transcriptase. Comparison with earlier modeling studies reveals that the predicted overlap of thiazoloisoindolinones with TIBO was largely correct, while that with nevirapine was significantly different.
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{{ABSTRACT_PUBMED_10508433}}


==About this Structure==
==About this Structure==
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[[Category: Hiv-1 reverse transcriptase]]
[[Category: Hiv-1 reverse transcriptase]]
[[Category: Non-nucleoside inhibitor]]
[[Category: Non-nucleoside inhibitor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:11:55 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:03:11 2008''

Revision as of 17:03, 30 June 2008

File:1c0t.png

Template:STRUCTURE 1c0t

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH BM+21.1326

Template:ABSTRACT PUBMED 10508433

About this Structure

1C0T is a Protein complex structure of sequences from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Crystallographic analysis of the binding modes of thiazoloisoindolinone non-nucleoside inhibitors to HIV-1 reverse transcriptase and comparison with modeling studies., Ren J, Esnouf RM, Hopkins AL, Stuart DI, Stammers DK, J Med Chem. 1999 Sep 23;42(19):3845-51. PMID:10508433

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