1c3a: Difference between revisions

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[[Image:1c3a.gif|left|200px]]
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[[Image:1c3a.png|left|200px]]


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{{STRUCTURE_1c3a|  PDB=1c3a  |  SCENE=  }}  
{{STRUCTURE_1c3a|  PDB=1c3a  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF FLAVOCETIN-A FROM THE HABU SNAKE VENOM, A NOVEL CYCLIC TETRAMER OF C-TYPE LECTIN-LIKE HETERODIMERS'''
===CRYSTAL STRUCTURE OF FLAVOCETIN-A FROM THE HABU SNAKE VENOM, A NOVEL CYCLIC TETRAMER OF C-TYPE LECTIN-LIKE HETERODIMERS===




==Overview==
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Snake venom contains a number of the hemostatically active C-type lectin-like proteins, which affect the interaction between von Willebrand factor (vWF) and the platelet glycoprotein (GP) Ib or platelet receptor to inhibit/induce platelet activation. Flavocetin-A (FL-A) is a high-molecular mass C-type lectin-like protein (149 kDa) isolated from the habu snake venom. FL-A binds with high affinity to the platelet GP Ibalpha-subunit and functions as a strong inhibitor of vWF-dependent platelet aggregation. We have determined the X-ray crystal structure of FL-A and refined to 2.5 A resolution. This is a first elucidation of a three-dimensional structure of the platelet GP Ib-binding protein. The overall structure reveals that the molecule is a novel cyclic tetramer (alphabeta)(4) made up of four alphabeta-heterodimers related by a crystallographic 4-fold symmetry. The tetramerization is mediated by an interchain disulfide bridge between cysteine residues at the C-terminus of the alpha-subunit and at the N-terminus of the beta-subunit in the neighboring alphabeta-heterodimer. The high affinity of FL-A for the platelet GP Ib alpha-subunit could be explained by a cooperative-binding action through the multiple binding sites of the tetramer.
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{{ABSTRACT_PUBMED_10684640}}


==About this Structure==
==About this Structure==
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[[Category: Morita, T.]]
[[Category: Morita, T.]]
[[Category: C-type lectin-like domain]]
[[Category: C-type lectin-like domain]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:16:34 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:08:53 2008''

Revision as of 17:08, 30 June 2008

File:1c3a.png

Template:STRUCTURE 1c3a

CRYSTAL STRUCTURE OF FLAVOCETIN-A FROM THE HABU SNAKE VENOM, A NOVEL CYCLIC TETRAMER OF C-TYPE LECTIN-LIKE HETERODIMERS

Template:ABSTRACT PUBMED 10684640

About this Structure

1C3A is a Protein complex structure of sequences from Trimeresurus flavoviridis. Full crystallographic information is available from OCA.

Reference

Crystal structure of flavocetin-A, a platelet glycoprotein Ib-binding protein, reveals a novel cyclic tetramer of C-type lectin-like heterodimers., Fukuda K, Mizuno H, Atoda H, Morita T, Biochemistry. 2000 Feb 29;39(8):1915-23. PMID:10684640

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