1c5b: Difference between revisions

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[[Image:1c5b.gif|left|200px]]
{{Seed}}
[[Image:1c5b.png|left|200px]]


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{{STRUCTURE_1c5b|  PDB=1c5b  |  SCENE=  }}  
{{STRUCTURE_1c5b|  PDB=1c5b  |  SCENE=  }}  


'''DECARBOXYLASE CATALYTIC ANTIBODY 21D8 UNLIGANDED FORM'''
===DECARBOXYLASE CATALYTIC ANTIBODY 21D8 UNLIGANDED FORM===




==Overview==
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Antibody 21D8 catalyzes the solvent-sensitive decarboxylation of 3-carboxybenzisoxazoles. The crystal structure of chimeric Fab 21D8 with and without hapten at 1.61 A and 2.10 A, respectively, together with computational analysis, shows how a melange of polar and non-polar sites are exploited to achieve both substrate binding and acceleration of a reaction normally facilitated by purely aprotic dipolar media. The striking similarity of the decarboxylase and a series of unrelated esterase antibodies also highlights the chemical versatility of structurally conserved anion binding sites and the relatively subtle changes involved in fine-tuning the immunoglobulin pocket for recognition of different ligands and catalysis of different reactions.
The line below this paragraph, {{ABSTRACT_PUBMED_11183784}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_11183784}}


==About this Structure==
==About this Structure==
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[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
[[Category: Unliganded]]
[[Category: Unliganded]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:20:46 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:13:46 2008''

Revision as of 17:13, 30 June 2008

File:1c5b.png

Template:STRUCTURE 1c5b

DECARBOXYLASE CATALYTIC ANTIBODY 21D8 UNLIGANDED FORM

Template:ABSTRACT PUBMED 11183784

About this Structure

Full crystallographic information is available from OCA.

Reference

Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structures of abzyme 21D8., Hotta K, Lange H, Tantillo DJ, Houk KN, Hilvert D, Wilson IA, J Mol Biol. 2000 Oct 6;302(5):1213-25. PMID:11183784

Page seeded by OCA on Mon Jun 30 20:13:46 2008

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