1cah: Difference between revisions

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[[Image:1cah.gif|left|200px]]
{{Seed}}
[[Image:1cah.png|left|200px]]


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{{STRUCTURE_1cah|  PDB=1cah  |  SCENE=  }}  
{{STRUCTURE_1cah|  PDB=1cah  |  SCENE=  }}  


'''STRUCTURE OF COBALT CARBONIC ANHYDRASE COMPLEXED WITH BICARBONATE'''
===STRUCTURE OF COBALT CARBONIC ANHYDRASE COMPLEXED WITH BICARBONATE===




==Overview==
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The three-dimensional structure of a complex between catalytically active cobalt(II) substituted human carbonic anhydrase II and its substrate bicarbonate was determined by X-ray crystallography (1.9 A). One water molecule and two bicarbonate oxygen atoms are found at distances between 2.3 and 2.5 A from the cobalt ion in addition to the three histidyl ligands contributed by the peptide chain. The tetrahedral geometry around the metal ion in the native enzyme with a single water molecule 2.0 A from the metal is therefore lost. The geometry is difficult to classify but might best be described as distorted octahedral. The structure is suggested to represent a water-bicarbonate exchange state relevant also for native carbonic anhydrase, where the two unprotonized oxygen atoms of the substrate are bound in a carboxylate binding site and the hydroxyl group is free to move closer to the metal thereby replacing the metal-bound water molecule. A reaction mechanism based on crystallographically determined enzyme-ligand complexes is represented.
The line below this paragraph, {{ABSTRACT_PUBMED_1474587}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_1474587}}


==About this Structure==
==About this Structure==
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[[Category: Hakansson, K.]]
[[Category: Hakansson, K.]]
[[Category: Wehnert, A.]]
[[Category: Wehnert, A.]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:31:28 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:28:37 2008''

Revision as of 17:28, 30 June 2008

File:1cah.png

Template:STRUCTURE 1cah

STRUCTURE OF COBALT CARBONIC ANHYDRASE COMPLEXED WITH BICARBONATE

Template:ABSTRACT PUBMED 1474587

About this Structure

1CAH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of cobalt carbonic anhydrase complexed with bicarbonate., Hakansson K, Wehnert A, J Mol Biol. 1992 Dec 20;228(4):1212-8. PMID:1474587

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