1cd9: Difference between revisions

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[[Image:1cd9.~~gif~~|left|200px]]

[[Image:1cd9.png|left|200px]]

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~~'''~~2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR~~'''~~

===2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR===

~~==Overview==~~

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~~Granulocyte colony~~-stimulating factor (GCSF) is the principal growth factor regulating the maturation, proliferation and differentiation of the precursor cells of neutrophilic granulocytes and is used to treat neutropenia. GCSF is a member of the long-~~chain subtype of the class 1 cytokine superfamily~~, ~~which includes growth hormone~~, ~~erythropoietin, interleukin 6 and oncostatin M. Here we have determined~~ the ~~crystal structure of GCSF complexed~~ to the ~~BN-BC domains, the principal ligand-binding region of the GCSF receptor~~ (~~GCSFR~~)~~. The two receptor domains form a complex in a 2:2 ratio with the ligand~~, ~~with a non-crystallographic pseudo-twofold axis through primarily~~ the ~~interdomain region and secondarily the BC domain~~. ~~This structural view of a gp130~~-~~type receptor~~-~~ligand complex presents a new molecular basis for cytokine-receptor recognition.~~

The line below this paragraph, {{ABSTRACT_PUBMED_10537111}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10537111 is the PubMed ID number.

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==About this Structure==

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[[Category: Hematopoietic receptor]]

[[Category: Signal transduction]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 12~~:36:07 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:34:57 2008''

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-[[Image:1cd9.gif|left|200px]]
+{{Seed}}
+[[Image:1cd9.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1cd9|  PDB=1cd9  |  SCENE=  }}
-'''2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR'''
+===2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR===
-==Overview==
+<!--
-Granulocyte colony-stimulating factor (GCSF) is the principal growth factor regulating the maturation, proliferation and differentiation of the precursor cells of neutrophilic granulocytes and is used to treat neutropenia. GCSF is a member of the long-chain subtype of the class 1 cytokine superfamily, which includes growth hormone, erythropoietin, interleukin 6 and oncostatin M. Here we have determined the crystal structure of GCSF complexed to the BN-BC domains, the principal ligand-binding region of the GCSF receptor (GCSFR). The two receptor domains form a complex in a 2:2 ratio with the ligand, with a non-crystallographic pseudo-twofold axis through primarily the interdomain region and secondarily the BC domain. This structural view of a gp130-type receptor-ligand complex presents a new molecular basis for cytokine-receptor recognition.
+The line below this paragraph, {{ABSTRACT_PUBMED_10537111}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10537111 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10537111}}
 ==About this Structure==
@@ Line 32: / Line 36: @@
 [[Category: Hematopoietic receptor]]
 [[Category: Signal transduction]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:36:07 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:34:57 2008''