1cft: Difference between revisions

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[[Image:1cft.~~jpg~~|left|200px]]

[[Image:1cft.png|left|200px]]

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~~'''~~ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE-UNRELATED D-PEPTIDE~~'''~~

===ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE-UNRELATED D-PEPTIDE===

~~==Overview==~~

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The ~~X-ray crystal structures of an anti-p24 (HIV-1) monoclonal antibody Fab fragment alone and in complexes with~~ the ~~epitope peptide GATPQDLNTnL~~ (~~n = norleucine), an epitope-homologous peptide GATPEDLNQKLAGN, as well~~ as ~~two unrelated peptides GLYEWGGARITNTD and efslkGpllqwrsG (D-peptide), are presented to a maximum resolution of 2~~.~~6 A~~. ~~The latter three peptides were identified from screening synthetic combinatorial peptide libraries. Although all peptides bind to the same antigen combining site~~, the nonhomologous peptides adopt different binding conformations and also form their critical contacts with different antibody residues. Only small readjustments are observed within the framework of the Fab fragment upon binding.

The line below this paragraph, {{ABSTRACT_PUBMED_9413990}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 9413990 is the PubMed ID number.

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==About this Structure==

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[[Category: Peptide]]

[[Category: Polyspecificity]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 12~~:41:25 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:41:33 2008''

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-[[Image:1cft.jpg|left|200px]]
+{{Seed}}
+[[Image:1cft.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1cft|  PDB=1cft  |  SCENE=  }}
-'''ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE-UNRELATED D-PEPTIDE'''
+===ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE-UNRELATED D-PEPTIDE===
-==Overview==
+<!--
-The X-ray crystal structures of an anti-p24 (HIV-1) monoclonal antibody Fab fragment alone and in complexes with the epitope peptide GATPQDLNTnL (n = norleucine), an epitope-homologous peptide GATPEDLNQKLAGN, as well as two unrelated peptides GLYEWGGARITNTD and efslkGpllqwrsG (D-peptide), are presented to a maximum resolution of 2.6 A. The latter three peptides were identified from screening synthetic combinatorial peptide libraries. Although all peptides bind to the same antigen combining site, the nonhomologous peptides adopt different binding conformations and also form their critical contacts with different antibody residues. Only small readjustments are observed within the framework of the Fab fragment upon binding.
+The line below this paragraph, {{ABSTRACT_PUBMED_9413990}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9413990 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9413990}}
 ==About this Structure==
@@ Line 31: / Line 35: @@
 [[Category: Peptide]]
 [[Category: Polyspecificity]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:41:25 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:41:33 2008''