1cit: Difference between revisions

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~~'''~~DNA-BINDING MECHANISM OF THE MONOMERIC ORPHAN NUCLEAR RECEPTOR NGFI-B~~'''~~

===DNA-BINDING MECHANISM OF THE MONOMERIC ORPHAN NUCLEAR RECEPTOR NGFI-B===

~~==Overview==~~

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The ~~2.7 A X-ray crystal structure of the DNA-binding domain (DBD) of the orphan nuclear receptor~~, ~~nerve growth factor-induced-B (NGFI-B)~~, ~~complexed~~ to ~~its high-affinity DNA target, represents~~ the ~~first structure analysis of a nuclear receptor DBD bound~~ as ~~a monomer to DNA~~. The structure of the core DBD and its interactions with the major groove of the DNA are similar to previously crystallographically solved DBD-DNA complexes in this superfamily; however, residues C-terminal to this core form a separate and unique substructure that interacts extensively and in a sequence-specific way with the minor groove of its DNA target, ~~in particular with~~ the ~~characteristic 3 A~~-~~T base~~-~~pair identity element that extends 5' to the usual nuclear receptor half-site (AGGTCA).~~

The line below this paragraph, {{ABSTRACT_PUBMED_10331876}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10331876 is the PubMed ID number.

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==About this Structure==

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[[Category: Protein/dna]]

[[Category: Transcription factor]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 12~~:46:36 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:48:16 2008''

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-[[Image:1cit.gif|left|200px]]
+{{Seed}}
+[[Image:1cit.png|left|200px]]
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 {{STRUCTURE_1cit|  PDB=1cit  |  SCENE=  }}
-'''DNA-BINDING MECHANISM OF THE MONOMERIC ORPHAN NUCLEAR RECEPTOR NGFI-B'''
+===DNA-BINDING MECHANISM OF THE MONOMERIC ORPHAN NUCLEAR RECEPTOR NGFI-B===
-==Overview==
+<!--
-The 2.7 A X-ray crystal structure of the DNA-binding domain (DBD) of the orphan nuclear receptor, nerve growth factor-induced-B (NGFI-B), complexed to its high-affinity DNA target, represents the first structure analysis of a nuclear receptor DBD bound as a monomer to DNA. The structure of the core DBD and its interactions with the major groove of the DNA are similar to previously crystallographically solved DBD-DNA complexes in this superfamily; however, residues C-terminal to this core form a separate and unique substructure that interacts extensively and in a sequence-specific way with the minor groove of its DNA target, in particular with the characteristic 3 A-T base-pair identity element that extends 5' to the usual nuclear receptor half-site (AGGTCA).
+The line below this paragraph, {{ABSTRACT_PUBMED_10331876}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10331876 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10331876}}
 ==About this Structure==
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 [[Category: Protein/dna]]
 [[Category: Transcription factor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:46:36 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:48:16 2008''