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[[Image:1cmi.gif|left|200px]]
{{Seed}}
[[Image:1cmi.png|left|200px]]


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{{STRUCTURE_1cmi|  PDB=1cmi  |  SCENE=  }}  
{{STRUCTURE_1cmi|  PDB=1cmi  |  SCENE=  }}  


'''STRUCTURE OF THE HUMAN PIN/LC8 DIMER WITH A BOUND PEPTIDE'''
===STRUCTURE OF THE HUMAN PIN/LC8 DIMER WITH A BOUND PEPTIDE===




==Overview==
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The structure of the protein known both as neuronal nitric oxide synthase inhibitory protein, PIN (protein inhibitor of nNOS), and also as the 8 kDa dynein light chain (LC8) has been solved by X-ray diffraction. Two PIN/LC8 monomers related by a two-fold axis form a rectangular dimer. Two pairs of alpha-helices cover opposite faces, and each pair of helices packs against a beta-sheet with five antiparallel beta-strands. Each five-stranded beta-sheet contains four strands from one monomer and a fifth strand from the other monomer. A 13-residue peptide from nNOS is bound to the dimer in a deep hydrophobic groove as a sixth antiparallel beta-strand. The structure provides key insights into dimerization of and peptide binding by the multifunctional PIN/LC8 protein.
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{{ABSTRACT_PUBMED_10426949}}


==About this Structure==
==About this Structure==
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[[Category: Nno]]
[[Category: Nno]]
[[Category: Pin]]
[[Category: Pin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:53:33 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:57:00 2008''

Revision as of 17:57, 30 June 2008

File:1cmi.png

Template:STRUCTURE 1cmi

STRUCTURE OF THE HUMAN PIN/LC8 DIMER WITH A BOUND PEPTIDE

Template:ABSTRACT PUBMED 10426949

About this Structure

1CMI is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1b1w. Full crystallographic information is available from OCA.

Reference

Structure of the PIN/LC8 dimer with a bound peptide., Liang J, Jaffrey SR, Guo W, Snyder SH, Clardy J, Nat Struct Biol. 1999 Aug;6(8):735-40. PMID:10426949

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