1cq3: Difference between revisions

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[[Image:1cq3.~~jpg~~|left|200px]]

[[Image:1cq3.png|left|200px]]

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~~'''~~STRUCTURE OF A SOLUBLE SECRETED CHEMOKINE INHIBITOR, VCCI, FROM COWPOX VIRUS~~'''~~

===STRUCTURE OF A SOLUBLE SECRETED CHEMOKINE INHIBITOR, VCCI, FROM COWPOX VIRUS===

~~==Overview==~~

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~~Most poxviruses~~, ~~including variola~~, the ~~causative agent of smallpox, express a secreted protein of 35 kDa, vCCI, which binds CC-chemokines with high affinity. This viral protein competes with~~ the ~~host cellular CC-chemokine receptors~~ (~~CCRs), reducing inflammation and interfering with the host immune response. Such proteins or derivatives may have therapeutic uses~~ as ~~anti-inflammatory agents~~. ~~We have determined the crystal structure to 1~~.~~85-A resolution of vCCI from cowpox virus~~, the ~~prototype of this poxvirus virulence factor~~. ~~The molecule is a beta~~-~~sandwich of topology not previously described. A patch of conserved residues on the exposed face of a beta~~-~~sheet that is strongly negatively charged might have a role in binding of CC-chemokines, which are positively charged.~~

The line below this paragraph, {{ABSTRACT_PUBMED_10535930}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10535930 is the PubMed ID number.

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==About this Structure==

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[[Category: Beta sandwich]]

[[Category: Chemokine]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 12~~:59:37 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:05:41 2008''

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-[[Image:1cq3.jpg|left|200px]]
+{{Seed}}
+[[Image:1cq3.png|left|200px]]
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 {{STRUCTURE_1cq3|  PDB=1cq3  |  SCENE=  }}
-'''STRUCTURE OF A SOLUBLE SECRETED CHEMOKINE INHIBITOR, VCCI, FROM COWPOX VIRUS'''
+===STRUCTURE OF A SOLUBLE SECRETED CHEMOKINE INHIBITOR, VCCI, FROM COWPOX VIRUS===
-==Overview==
+<!--
-Most poxviruses, including variola, the causative agent of smallpox, express a secreted protein of 35 kDa, vCCI, which binds CC-chemokines with high affinity. This viral protein competes with the host cellular CC-chemokine receptors (CCRs), reducing inflammation and interfering with the host immune response. Such proteins or derivatives may have therapeutic uses as anti-inflammatory agents. We have determined the crystal structure to 1.85-A resolution of vCCI from cowpox virus, the prototype of this poxvirus virulence factor. The molecule is a beta-sandwich of topology not previously described. A patch of conserved residues on the exposed face of a beta-sheet that is strongly negatively charged might have a role in binding of CC-chemokines, which are positively charged.
+The line below this paragraph, {{ABSTRACT_PUBMED_10535930}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10535930 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10535930}}
 ==About this Structure==
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 [[Category: Beta sandwich]]
 [[Category: Chemokine]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:59:37 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:05:41 2008''