1cqe: Difference between revisions

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[[Image:1cqe.gif|left|200px]]
{{Seed}}
[[Image:1cqe.png|left|200px]]


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{{STRUCTURE_1cqe|  PDB=1cqe  |  SCENE=  }}  
{{STRUCTURE_1cqe|  PDB=1cqe  |  SCENE=  }}  


'''PROSTAGLANDIN H2 SYNTHASE-1 COMPLEX WITH FLURBIPROFEN'''
===PROSTAGLANDIN H2 SYNTHASE-1 COMPLEX WITH FLURBIPROFEN===




==Overview==
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The three-dimensional structure of prostaglandin H2 synthase-1, an integral membrane protein, has been determined at 3.5 A resolution by X-ray crystallography. This bifunctional enzyme comprises three independent folding units: an epidermal growth factor domain, a membrane-binding motif and an enzymatic domain. Two adjacent but spatially distinct active sites were found for its haem-dependent peroxidase and cyclooxygenase activities. The cyclooxygenase active site is created by a long, hydrophobic channel that is the site of non-steroidal anti-inflammatory drug binding. The conformation of the membrane-binding motif strongly suggests that the enzyme integrates into only one leaflet of the lipid bilayer and is thus a monotopic membrane protein.
The line below this paragraph, {{ABSTRACT_PUBMED_8121489}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 8121489 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8121489}}


==About this Structure==
==About this Structure==
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[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Peroxidase]]
[[Category: Peroxidase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:00:09 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:07:36 2008''

Revision as of 18:07, 30 June 2008

File:1cqe.png

Template:STRUCTURE 1cqe

PROSTAGLANDIN H2 SYNTHASE-1 COMPLEX WITH FLURBIPROFEN

Template:ABSTRACT PUBMED 8121489

About this Structure

1CQE is a Single protein structure of sequence from Ovis aries. Full crystallographic information is available from OCA.

Reference

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1., Picot D, Loll PJ, Garavito RM, Nature. 1994 Jan 20;367(6460):243-9. PMID:8121489

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