1cqt: Difference between revisions

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[[Image:1cqt.~~gif~~|left|200px]]

[[Image:1cqt.png|left|200px]]

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~~'''~~CRYSTAL STRUCTURE OF A TERNARY COMPLEX CONTAINING AN OCA-B PEPTIDE, THE OCT-1 POU DOMAIN, AND AN OCTAMER ELEMENT~~'''~~

===CRYSTAL STRUCTURE OF A TERNARY COMPLEX CONTAINING AN OCA-B PEPTIDE, THE OCT-1 POU DOMAIN, AND AN OCTAMER ELEMENT===

~~==Overview==~~

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~~We have determined the crystal structure~~, ~~at 3.2 A, of a ternary complex containing an OCA-B peptide~~, the ~~Oct-1 POU domain, and an octamer DNA site. The OCA-B peptide binds in~~ the ~~major groove near the center of the octamer site, and its polypeptide backbone forms a pair of hydrogen bonds with the adenine base~~ at ~~position 5 of the octamer DNA~~. ~~Numerous protein-protein contacts between the OCA-B peptide and the POU domain are also involved in the ternary complex~~. ~~In particular~~, the ~~hydrophobic surface from a short alpha-helix of OCA-B helps to stabilize the complex by binding to a hydrophobic pocket on the POU-specific domain~~. ~~The structure of this ternary complex is consistent with previous biochemical studies and shows how peptide~~-~~DNA and peptide~~-~~protein contacts from OCA-B provide structural and functional specificity in the regulation of immunoglobulin transcription.~~

The line below this paragraph, {{ABSTRACT_PUBMED_10541551}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10541551 is the PubMed ID number.

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==About this Structure==

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[[Category: Protein-dna complex]]

[[Category: Protein-dna interface]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 13~~:01:03 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:09:44 2008''

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-[[Image:1cqt.gif|left|200px]]
+{{Seed}}
+[[Image:1cqt.png|left|200px]]
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 {{STRUCTURE_1cqt|  PDB=1cqt  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF A TERNARY COMPLEX CONTAINING AN OCA-B PEPTIDE, THE OCT-1 POU DOMAIN, AND AN OCTAMER ELEMENT'''
+===CRYSTAL STRUCTURE OF A TERNARY COMPLEX CONTAINING AN OCA-B PEPTIDE, THE OCT-1 POU DOMAIN, AND AN OCTAMER ELEMENT===
-==Overview==
+<!--
-We have determined the crystal structure, at 3.2 A, of a ternary complex containing an OCA-B peptide, the Oct-1 POU domain, and an octamer DNA site. The OCA-B peptide binds in the major groove near the center of the octamer site, and its polypeptide backbone forms a pair of hydrogen bonds with the adenine base at position 5 of the octamer DNA. Numerous protein-protein contacts between the OCA-B peptide and the POU domain are also involved in the ternary complex. In particular, the hydrophobic surface from a short alpha-helix of OCA-B helps to stabilize the complex by binding to a hydrophobic pocket on the POU-specific domain. The structure of this ternary complex is consistent with previous biochemical studies and shows how peptide-DNA and peptide-protein contacts from OCA-B provide structural and functional specificity in the regulation of immunoglobulin transcription.
+The line below this paragraph, {{ABSTRACT_PUBMED_10541551}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10541551 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10541551}}
 ==About this Structure==
@@ Line 32: / Line 36: @@
 [[Category: Protein-dna complex]]
 [[Category: Protein-dna interface]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:01:03 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:09:44 2008''