1csl: Difference between revisions

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[[Image:1csl.~~jpg~~|left|200px]]

[[Image:1csl.png|left|200px]]

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~~'''~~CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE~~'''~~

===CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE===

~~==Overview==~~

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The ~~crystal structure of a 28 nt RNA fragment containing~~ the ~~human immunodeficiency virus type 1~~ (~~HIV-1) Rev response element high affinity binding site for Rev protein has been solved~~ at 1.~~6 A resolution~~. ~~The overall structure of the RRE helix~~ is ~~greatly distorted from A-form geometry by~~ the ~~presence of two purine-purine base-pairs and two single nucleotide bulges~~. ~~G48 and G71 form a Hoogsteen~~-~~type asymmetric base~~-pair with G71 adopting a syn conformation. The non-canonical regions in the unliganded Rev response element molecule narrow the major groove width with respect to standard A-RNA. The Rev response element structure observed here represents a closed form of the Rev binding site and differs from conformations of the RNA observed previously by solution NMR studies.

The line below this paragraph, {{ABSTRACT_PUBMED_10656783}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10656783 is the PubMed ID number.

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==About this Structure==

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[[Category: Hiv-1]]

[[Category: Rre high affinity site]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 13~~:04:18 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:17:37 2008''

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-[[Image:1csl.jpg|left|200px]]
+{{Seed}}
+[[Image:1csl.png|left|200px]]
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 {{STRUCTURE_1csl|  PDB=1csl  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE'''
+===CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE===
-==Overview==
+<!--
-The crystal structure of a 28 nt RNA fragment containing the human immunodeficiency virus type 1 (HIV-1) Rev response element high affinity binding site for Rev protein has been solved at 1.6 A resolution. The overall structure of the RRE helix is greatly distorted from A-form geometry by the presence of two purine-purine base-pairs and two single nucleotide bulges. G48 and G71 form a Hoogsteen-type asymmetric base-pair with G71 adopting a syn conformation. The non-canonical regions in the unliganded Rev response element molecule narrow the major groove width with respect to standard A-RNA. The Rev response element structure observed here represents a closed form of the Rev binding site and differs from conformations of the RNA observed previously by solution NMR studies.
+The line below this paragraph, {{ABSTRACT_PUBMED_10656783}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10656783 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10656783}}
 ==About this Structure==
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 [[Category: Hiv-1]]
 [[Category: Rre high affinity site]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:04:18 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:17:37 2008''