1d0b: Difference between revisions

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[[Image:1d0b.jpg|left|200px]]
{{Seed}}
[[Image:1d0b.png|left|200px]]


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{{STRUCTURE_1d0b|  PDB=1d0b  |  SCENE=  }}  
{{STRUCTURE_1d0b|  PDB=1d0b  |  SCENE=  }}  


'''INTERNALIN B LEUCINE RICH REPEAT DOMAIN'''
===INTERNALIN B LEUCINE RICH REPEAT DOMAIN===




==Overview==
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The L. monocytogenes protein lnlB activates phosphoinositide 3-kinase and induces phagocytosis in several mammalian cell types. The 1.86 A resolution X-ray crystal structure of the leucine-rich repeat domain of lnlB that is both necessary and sufficient to induce phagocytosis is presented here. The structure supports a crucial role for calcium in host cell invasion by L. monocytogenes and supplies a rationale for its function. Calciums are bound to the protein in an unusually exposed manner that suggests that the metals may act as a bridge between lnlB and mammalian cell surface receptors. The structure also identifies surfaces on the curved and elongated molecule that may constitute additional interaction sites in forming a bacterial-mammalian signaling complex.
The line below this paragraph, {{ABSTRACT_PUBMED_10635330}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_10635330}}


==About this Structure==
==About this Structure==
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[[Category: Calcium binding]]
[[Category: Calcium binding]]
[[Category: Leucine rich repeat]]
[[Category: Leucine rich repeat]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:18:06 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:55:57 2008''

Revision as of 18:55, 30 June 2008

File:1d0b.png

Template:STRUCTURE 1d0b

INTERNALIN B LEUCINE RICH REPEAT DOMAIN

Template:ABSTRACT PUBMED 10635330

About this Structure

1D0B is a Single protein structure of sequence from Listeria monocytogenes. Full crystallographic information is available from OCA.

Reference

Structure of the lnlB leucine-rich repeats, a domain that triggers host cell invasion by the bacterial pathogen L. monocytogenes., Marino M, Braun L, Cossart P, Ghosh P, Mol Cell. 1999 Dec;4(6):1063-72. PMID:10635330

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