1d2z: Difference between revisions

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[[Image:1d2z.gif|left|200px]]
{{Seed}}
[[Image:1d2z.png|left|200px]]


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{{STRUCTURE_1d2z|  PDB=1d2z  |  SCENE=  }}  
{{STRUCTURE_1d2z|  PDB=1d2z  |  SCENE=  }}  


'''THREE-DIMENSIONAL STRUCTURE OF A COMPLEX BETWEEN THE DEATH DOMAINS OF PELLE AND TUBE'''
===THREE-DIMENSIONAL STRUCTURE OF A COMPLEX BETWEEN THE DEATH DOMAINS OF PELLE AND TUBE===




==Overview==
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The interaction of the serine/threonine kinase Pelle and adaptor protein Tube through their N-terminal death domains leads to the nuclear translocation of the transcription factor Dorsal and activation of zygotic patterning genes during Drosophila embryogenesis. Crystal structure of the Pelle and Tube death domain heterodimer reveals that the two death domains adopt a six-helix bundle fold and are arranged in an open-ended linear array with plastic interfaces mediating their interactions. The Tube death domain has an insertion between helices 2 and 3, and a C-terminal tail making significant and indispensable contacts in the heterodimer. In vivo assays of Pelle and Tube mutants confirmed that the integrity of the major heterodimer interface is critical to the activity of these molecules.
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{{ABSTRACT_PUBMED_10589682}}


==About this Structure==
==About this Structure==
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[[Category: Plastic interface]]
[[Category: Plastic interface]]
[[Category: Six-helix bundle]]
[[Category: Six-helix bundle]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:23:36 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:14:55 2008''

Revision as of 19:14, 30 June 2008

File:1d2z.png

Template:STRUCTURE 1d2z

THREE-DIMENSIONAL STRUCTURE OF A COMPLEX BETWEEN THE DEATH DOMAINS OF PELLE AND TUBE

Template:ABSTRACT PUBMED 10589682

About this Structure

1D2Z is a Protein complex structure of sequences from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of a complex between the death domains of Pelle and Tube., Xiao T, Towb P, Wasserman SA, Sprang SR, Cell. 1999 Nov 24;99(5):545-55. PMID:10589682

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