1d6a: Difference between revisions

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[[Image:1d6a.~~gif~~|left|200px]]

[[Image:1d6a.png|left|200px]]

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~~'''~~STRUCTURE OF POKEWEED ANTIVIRAL PROTEIN COMPLEXED WITH GUANINE~~'''~~

===STRUCTURE OF POKEWEED ANTIVIRAL PROTEIN COMPLEXED WITH GUANINE===

~~==Overview==~~

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~~Pokeweed antiviral protein (PAP) is a ribosome-inactivating protein (RIP)~~, ~~which enzymatically removes a single adenine base from a conserved~~, ~~surface exposed loop sequence of ribosomal rRNA. We now present unprecedented experimental evidence that PAP can release not only adenine but guanine~~ as ~~well from Escherichia coli rRNA, albeit~~ at ~~a rate 20 times slower than for adenine~~. ~~We also report X-ray structure analysis and supporting modeling studies for the interactions of PAP with guanine~~. ~~Our modeling studies indicated that PAP can accommodate a guanine base in~~ the ~~active site pocket without large conformational changes~~. ~~This prediction was experimentally confirmed, since a guanine base was visible in the active site pocket of the crystal structure of the PAP~~-~~guanine complex.~~

The line below this paragraph, {{ABSTRACT_PUBMED_10595542}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10595542 is the PubMed ID number.

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==About this Structure==

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[[Category: Pokeweed antiviral protein]]

[[Category: Ribosome inactivating protein]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 13~~:29:55 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:31:38 2008''

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-[[Image:1d6a.gif|left|200px]]
+{{Seed}}
+[[Image:1d6a.png|left|200px]]
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 {{STRUCTURE_1d6a|  PDB=1d6a  |  SCENE=  }}
-'''STRUCTURE OF POKEWEED ANTIVIRAL PROTEIN COMPLEXED WITH GUANINE'''
+===STRUCTURE OF POKEWEED ANTIVIRAL PROTEIN COMPLEXED WITH GUANINE===
-==Overview==
+<!--
-Pokeweed antiviral protein (PAP) is a ribosome-inactivating protein (RIP), which enzymatically removes a single adenine base from a conserved, surface exposed loop sequence of ribosomal rRNA. We now present unprecedented experimental evidence that PAP can release not only adenine but guanine as well from Escherichia coli rRNA, albeit at a rate 20 times slower than for adenine. We also report X-ray structure analysis and supporting modeling studies for the interactions of PAP with guanine. Our modeling studies indicated that PAP can accommodate a guanine base in the active site pocket without large conformational changes. This prediction was experimentally confirmed, since a guanine base was visible in the active site pocket of the crystal structure of the PAP-guanine complex.
+The line below this paragraph, {{ABSTRACT_PUBMED_10595542}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10595542 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10595542}}
 ==About this Structure==
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 [[Category: Pokeweed antiviral protein]]
 [[Category: Ribosome inactivating protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:29:55 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:31:38 2008''