1d6b: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
[[Image:1d6b.jpg|left|200px]]
{{Seed}}
[[Image:1d6b.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1d6b|  PDB=1d6b  |  SCENE=  }}  
{{STRUCTURE_1d6b|  PDB=1d6b  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF DEFENSIN-LIKE PEPTIDE-2 (DLP-2) FROM PLATYPUS VENOM'''
===SOLUTION STRUCTURE OF DEFENSIN-LIKE PEPTIDE-2 (DLP-2) FROM PLATYPUS VENOM===




==Overview==
<!--
The venom of the male Australian duck-billed platypus contains a family of four polypeptides of appox. 5 kDa, which are referred to as defensin-like peptides (DLPs). They are unique in that their amino acid sequences have no significant similarities to those of any known peptides; however, the tertiary structure of one of them, DLP-1, has recently been shown to be similar to beta-defensin-12 and to the sodium neurotoxin peptide ShI (Stichodactyla helianthus neurotoxin I). Although DLPs are the major peptides in the platypus venom, little is known about their biological roles. In this study, we determined the three-dimensional structure of DLP-2 by NMR spectroscopy, with the aim of gaining insights into the natural function of the DLPs in platypus venom. The DLP-2 structure was found to incorporate a short helix that spans residues 9-12, and an antiparallel beta-sheet defined by residues 15-18 and 37-40. The overall fold and cysteine-pairing pattern of DLP-2 were found to be similar to those of DLP-1, and hence beta-defensin-12; however, the sequence similarities between the three molecules are relatively small. The distinct structural fold of the DLP-1, DLP-2, and beta-defensin-12 is based upon several key residues that include six cysteines. DLP-3 and DLP-4 are also likely to be folded similarly since they have high sequence similarity with DLP-2. The DLPs, and beta-defensin-12 may thus be grouped together into a class of polypeptide molecules which have a common or very similar global fold. The fact that the DLPs did not display antimicrobial, myotoxic, or cell-growth-promoting activities implies that the nature of the side chains in this group of peptides is likely to play an important role in defining the biological function(s).
The line below this paragraph, {{ABSTRACT_PUBMED_10839998}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10839998 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_10839998}}


==About this Structure==
==About this Structure==
1D6B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ornithorhynchus_anatinus Ornithorhynchus anatinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D6B OCA].  
1D6B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ornithorhynchus_anatinus Ornithorhynchus anatinus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D6B OCA].  


==Reference==
==Reference==
Line 31: Line 35:
[[Category: Antiparallel beta-sheet]]
[[Category: Antiparallel beta-sheet]]
[[Category: Helix]]
[[Category: Helix]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:29:56 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:31:43 2008''

Revision as of 19:31, 30 June 2008

File:1d6b.png

Template:STRUCTURE 1d6b

SOLUTION STRUCTURE OF DEFENSIN-LIKE PEPTIDE-2 (DLP-2) FROM PLATYPUS VENOM

Template:ABSTRACT PUBMED 10839998

About this Structure

1D6B is a Single protein structure of sequence from Ornithorhynchus anatinus. Full experimental information is available from OCA.

Reference

Defensin-like peptide-2 from platypus venom: member of a class of peptides with a distinct structural fold., Torres AM, de Plater GM, Doverskog M, Birinyi-Strachan LC, Nicholson GM, Gallagher CH, Kuchel PW, Biochem J. 2000 Jun 15;348 Pt 3:649-56. PMID:10839998

Page seeded by OCA on Mon Jun 30 22:31:43 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1d6b&oldid=585949"