1d7o: Difference between revisions

Line 1:

[[Image:1d7o.~~jpg~~|left|200px]]

[[Image:1d7o.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~CRYSTAL STRUCTURE OF BRASSICA NAPUS ENOYL ACYL CARRIER PROTEIN REDUCTASE COMPLEXED WITH NAD AND TRICLOSAN~~'''~~

===CRYSTAL STRUCTURE OF BRASSICA NAPUS ENOYL ACYL CARRIER PROTEIN REDUCTASE COMPLEXED WITH NAD AND TRICLOSAN===

~~==Overview==~~

<!--

~~Molecular genetic studies with strains of Escherichia coli resistant to triclosan~~, ~~an ingredient of many anti-bacterial household goods~~, ~~have suggested that this compound works by acting~~ as ~~an inhibitor of enoyl reductase (ENR) and thereby blocking lipid biosynthesis~~. ~~We present structural analyses correlated with inhibition data, on the complexes of E~~. ~~coli and Brassica napus ENR with triclosan and NAD(+~~) ~~which reveal how triclosan acts as a site-directed~~, ~~picomolar inhibitor of~~ the enzyme by mimicking its natural substrate. Elements of both the protein and the nucleotide cofactor play important roles in triclosan recognition, providing an explanation for the factors controlling its tight binding to the enzyme and for the emergence of triclosan resistance.

The line below this paragraph, {{ABSTRACT_PUBMED_10610777}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10610777 is the PubMed ID number.

-->

==About this Structure==

Line 39:

Line 43:

[[Category: Enoyl reductase]]

[[Category: Triclosan]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 13~~:32:22 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:38:05 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1d7o.jpg|left|200px]]
+{{Seed}}
+[[Image:1d7o.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1d7o|  PDB=1d7o  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF BRASSICA NAPUS ENOYL ACYL CARRIER PROTEIN REDUCTASE COMPLEXED WITH NAD AND TRICLOSAN'''
+===CRYSTAL STRUCTURE OF BRASSICA NAPUS ENOYL ACYL CARRIER PROTEIN REDUCTASE COMPLEXED WITH NAD AND TRICLOSAN===
-==Overview==
+<!--
-Molecular genetic studies with strains of Escherichia coli resistant to triclosan, an ingredient of many anti-bacterial household goods, have suggested that this compound works by acting as an inhibitor of enoyl reductase (ENR) and thereby blocking lipid biosynthesis. We present structural analyses correlated with inhibition data, on the complexes of E. coli and Brassica napus ENR with triclosan and NAD(+) which reveal how triclosan acts as a site-directed, picomolar inhibitor of the enzyme by mimicking its natural substrate. Elements of both the protein and the nucleotide cofactor play important roles in triclosan recognition, providing an explanation for the factors controlling its tight binding to the enzyme and for the emergence of triclosan resistance.
+The line below this paragraph, {{ABSTRACT_PUBMED_10610777}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10610777 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10610777}}
 ==About this Structure==
@@ Line 39: / Line 43: @@
 [[Category: Enoyl reductase]]
 [[Category: Triclosan]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:32:22 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:38:05 2008''